Abstract | OBJECTIVES: METHODS: We measured plasma levels of BDNF and activities of GPx and SOD in individuals with BD (n=59) and healthy controls (n=26). Information related to current and past psychiatric/medical history, as well as to metabolic comorbidities, was also reported. RESULTS: There were negative correlations between BDNF, GPx (r=-.449, P≤.001) and GPx/SOD ratio (r=-.503, P<.001), and a positive correlation between BDNF and SOD (r=.254, P=.020). There was a moderating effect of body mass index (BMI) on the association between BDNF and GPx/SOD rate ratio [(RR)=1.002, P=.034]; interactions between impaired glucose metabolism ( IGM), GPx (RR=1.016, P=.033), and GPx/SOD ratio (RR=1.026, P=.002) were also observed. These results were significant in models that included age, gender, alcohol, tobacco and medication use. CONCLUSIONS: There was a robust and independent correlation between peripheral BDNF and antioxidant enzyme activities in individuals with BD, which was moderated by metabolic comorbidities. These results reinforce the concept that these systems are associated and further extend knowledge of the putative effect of metabolic comorbidities in the pathophysiological substrates of BD.
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Authors | Rodrigo B Mansur, Camila M Santos, Lucas B Rizzo, Graccielle R Cunha, Elson Asevedo, Mariane N Noto, Mariana Pedrini, Maiara Zeni, Quirino Cordeiro, Roger S McIntyre, Elisa Brietzke |
Journal | Bipolar disorders
(Bipolar Disord)
Vol. 18
Issue 5
Pg. 433-9
(08 2016)
ISSN: 1399-5618 [Electronic] Denmark |
PMID | 27488494
(Publication Type: Journal Article)
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Copyright | © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
Chemical References |
- Antioxidants
- Brain-Derived Neurotrophic Factor
- Glutathione Peroxidase
- Superoxide Dismutase
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Topics |
- Adult
- Antioxidants
(metabolism)
- Bipolar Disorder
(blood, metabolism)
- Brain-Derived Neurotrophic Factor
(blood)
- Female
- Glutathione Peroxidase
(metabolism)
- Humans
- Male
- Middle Aged
- Oxidation-Reduction
- Oxidative Stress
(physiology)
- Statistics as Topic
- Superoxide Dismutase
(metabolism)
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