Effects of D-allulose on glucose metabolism after the administration of sugar or food in healthy dogs.

Abstract

D-allulose is a C-3 epimer of D-fructose and has recently been investigated for its hypoglycemic effects. In the present study, the effects of D-allulose on glucose metabolism were evaluated in healthy dogs administrated sugar or food. The oral administrations of D-allulose decreased plasma glucose concentrations after oral glucose or maltose administration, with a diminished plasma insulin rise. The glucose suppressive effect of D-allulose was also observed after intravenous glucose administrations without increase in plasma insulin concentration. In contrast, D-allulose showed no effect on plasma glucose and insulin concentrations after feeding. The present results suggest that D-allulose administration may be beneficial in dogs with impaired glucose tolerance. Further studies investigating the therapeutic efficacy of D-allulose in diabetic dogs are required.

• Authors: Naohito Nishii, Toru Nomizo, Satoshi Takashima, Tatsuya Matsubara, Masaaki Tokuda, Hitoshi Kitagawa
• Journal: The Journal of veterinary medical science (J Vet Med Sci) Vol. 78 Issue 11 Pg. 1657-1662 (Dec 01 2016) ISSN: 1347-7439 [Electronic] Japan
• PMID: 27452736 (Publication Type: Journal Article)

Chemical References

• Blood Glucose
• Hypoglycemic Agents
• Insulin
• psicose
• Fructose
• Maltose
• Glucose

Topics

• Animals
• Blood Glucose (metabolism)
• Dogs (metabolism)
• Food
• Fructose (pharmacology)
• Glucose (administration & dosage, metabolism)
• Hypoglycemic Agents (pharmacology)
• Insulin (blood)
• Maltose (administration & dosage)
• Postprandial Period