Cumulative consumption of branched-chain amino acids and incidence of type 2 diabetes.

Abstract

BACKGROUND:

Plasma branched-chain amino acids (BCAAs, including leucine, isoleucine and valine) were recently related to risk of type 2 diabetes (T2D). Dietary intake is the only source of BCAAs; however, little is known about whether habitual dietary intake of BCAAs affects risk of T2D.

METHODS:

We assessed associations between cumulative consumption of BCAAs and risk of T2D among participants from three prospective cohorts: the Nurses' Health Study (NHS; followed from 1980 to 2012); NHS II (followed from 1991 to 2011); and the Health Professionals Follow-up Study (HPFS; followed from 1986 to 2010).

RESULTS:

We documented 16 097 incident T2D events during up to 32 years of follow-up. After adjustment for demographics and traditional risk factors, higher total BCAA intake was associated with an increased risk of T2D in men and women. In the meta-analysis of all cohorts, comparing participants in the highest quintile with those in the lowest quintile of intake, hazard ratios (95%confidence intervals) were for leucine 1.13 (1.07-1.19), for isoleucine 1.13 (1.07-1.19) and for valine 1.11 (1.05-1.17) (all P for trend < 0.001). In a healthy subsample, higher dietary BCAAs were significantly associated with higher plasma levels of these amino acids (P for trend = 0.01).

CONCLUSIONS:

Our data suggest that high consumption of BCAAs is associated with an increased risk of T2D.

• Authors: Yan Zheng, Yanping Li, Qibin Qi, Adela Hruby, JoAnn E Manson, Walter C Willett, Brian M Wolpin, Frank B Hu, Lu Qi
• Journal: International journal of epidemiology (Int J Epidemiol) Vol. 45 Issue 5 Pg. 1482-1492 (10 2016) ISSN: 1464-3685 [Electronic] England
• PMID: 27413102 (Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural)
• Copyright: © The Author 2016; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association.

Chemical References

• Amino Acids, Branched-Chain

Topics

• Adult
• Aged
• Amino Acids, Branched-Chain (administration & dosage)
• Diabetes Mellitus, Type 2 (epidemiology)
• Diet
• Female
• Humans
• Incidence
• Male
• Middle Aged
• Odds Ratio
• Prospective Studies
• Risk Factors
• United States