[Not Available].

Abstract

INTRODUCTION:

We present here results of methotrexate, in term of efficacy and tolerance, administrated in 21 Tunisian patients with severe psoriasis.

METHODS:

It was a retrospective study conducted between january 2002 and december 2009 in the department of dermatology of Charles Nicolle Hospital of Tunis. We have included 21 patients with severe psoriasis treated by methotrexate.

RESULTS:

Patients were 53year-middle aged with a sex-ratio=6. Psoriasis evolved for a mean of 10years (1month-60years). Patients had: plaque psoriasis (n=18, 85.8%) with 63% body surface involvement, erythrodermic psoriasis (n=2, 9.5%) and psoriatic arthritis (n=1, 4.7%). Methotrexate was orally administrated at an initial dose of 5-7.5mg/week. The maximum dose was of 7.5mg-12.5mg/week. Complete remission was achieved in 62% of cases and partial remission in 28.5% of cases. Haematological and hepatic toxicities were observed in 2 patients (9.5%). Mean remission period was of 14months (3months-3years). Seven patients had severe relapses.

CONCLUSION:

Our study concluded to the efficacy of methotrexate in severe psoriasis with a high rate and long term remission, despite lower doses than those classically used in the literature.

• Authors: Aida Khaled, Myriam Ben Hamida, Faten Zeglaoui, Monia Kharfi, Nadia Ezzine, Becima Fazaa
• Journal: Therapie (Therapie) 2012 Jan-Feb Vol. 67 Issue 1 Pg. 49-52 ISSN: 0040-5957 [Print] France
• Vernacular Title: Traitement du psoriasis par méthotrexate à l'ère des biothérapies : étude chez 21 patients tunisiens.
• PMID: 27393658 (Publication Type: English Abstract, Journal Article)
• Copyright: Copyright © 2012 Société Française de Pharmacologie et de Thérapeutique. Publié par Elsevier Masson SAS.