[Acute liver failure after ingestion of death cap mushrooms].

Abstract

Amatoxins, which are mainly found in Amanita phalloides, Amanita virosa, and Galerina autumnalis, are responsible for the majority of fatal intoxication with green death cap. The intoxication is associated with acute liver failure, which explains the poor prognosis. Acute liver injury is generally preceeded by a gastrointestinal phase with nausea, vomiting and diarrhea. In the course, pre-renal kidney failure due to the associated fluid deficit and fulminant liver failure may occur. General guidelines for the treatment of amatoxin poisoning are yet not available. We report on three patients who suffered from amatoxin mushroom poisoning after ingestion of green death cap mushrooms. Based on the pathophysiology of amatoxin poisoning, we discuss a potential therapeutic approach.

• Authors: Anna-Maria Zuliani, Iyad Kabar, Todd Mitchell, Hauke Sebastian Heinzow
• Journal: Deutsche medizinische Wochenschrift (1946) (Dtsch Med Wochenschr) Vol. 141 Issue 13 Pg. 940-2 (Jul 2016) ISSN: 1439-4413 [Electronic] Germany
• Vernacular Title: Akutes Leberversagen nach Knollenblätterpilz-Ingestion.
• PMID: 27359312 (Publication Type: Case Reports, Journal Article)
• Copyright: © Georg Thieme Verlag KG Stuttgart · New York.

Topics

• Adult
• Chemical and Drug Induced Liver Injury (diagnosis, diagnostic imaging, therapy)
• Female
• Humans
• Liver Failure, Acute (diagnosis, therapy)
• Male
• Middle Aged
• Mushroom Poisoning (diagnosis, therapy)
• Treatment Outcome