[Mechanism Study on Danggui Shaoyao San and Guizhi Fuling Wan For Treating Primary Dysmenorrheal Based on Biological Network].

Abstract

OBJECTIVE:

To investigate the molecular mechanisms of Danggui Shaoyao San and Guizhi Fuling Wan for treating primary dysmenorrhea of liver depression and blood stasis syndrome by biological network method.

METHODS:

Targets of the formula were collected from. PubMed database, and targets of primary dysmenorrhea were searched from Gene Card database. Then, the "formula-syndromes-disease" network was constructed and analyzed with Cytoscape software. Molecular docking approach was used to verify estrogen-like effect of ingredients.

RESULTS:

The "formula-syndromes-disease" shared multiple targets, which involves a variety of important nodes, such as IL and PGF2α, and played the effects of anti-inflammatory and analgesic. Danggui Shaoyao San could influence the function of hormones, such as corticotropin releasing hormone, and inhibit hyperactivity of adrenal axis. Guizhi Fuling Wan mainly affected a series of inflammation caused by cyclooxygenase and had the effects of blood coagulation. Estrogen-like effect of Danggui Shaoyao Sanwas stronger than that of Guizhi Fuling Wan.

CONCLUSION:

The novel approach will present an effective strategy for theory study of Danggui Shaoyao San and Guizhi Fuling Wan for treating primary dysmenorrhea.

• Authors: Yun-lai Wang, Si-yao Ru, Qing Fang, Gun-qiang Li, Yong-fu Pan, Yao Yao, Fan Xu
• Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials (Zhong Yao Cai) Vol. 38 Issue 11 Pg. 2348-52 (Nov 2015) ISSN: 1001-4454 [Print] China
• PMID: 27356390 (Publication Type: Journal Article)

Chemical References

• Drugs, Chinese Herbal
• danggui-shaoyao-san
• guizhi-fuling

Topics

• Blood Coagulation
• Drugs, Chinese Herbal (therapeutic use)
• Dysmenorrhea (drug therapy)
• Female
• Humans
• Inflammation (drug therapy)
• Molecular Docking Simulation