d-Allose Attenuates Overexpression of Inflammatory Cytokines after Cerebral Ischemia/Reperfusion Injury in Gerbil.

Abstract

BACKGROUND:

The present study investigates the effects of d-allose, a rare sugar, on the inflammatory response after transient forebrain ischemia in the gerbil and whether it reduces oxidative stress (8-hydroxyl-2'-deoxyguanosine levels) and behavioral deficits.

METHODS:

Transient forebrain ischemia was induced by occlusion of the bilateral common carotid arteries for 5 minutes. d-Allose was intraperitoneally injected immediately after ischemia (400 mg/kg). Inflammatory cytokines and oxidative damage in the hippocampus and behavioral deficits were examined 3 days after ischemia.

RESULTS:

d-Allose administration reduced ischemia-induced cytokine production, oxidative stress, and behavioral deficits (motor and memory related).

CONCLUSIONS:

The present results suggest that d-allose reduces brain injury after transient global ischemia by suppressing inflammation as well as by inhibiting oxidative stress.

• Authors: Natsuyo Shinohara, Takehiro Nakamura, Yuko Abe, Toru Hifumi, Kenya Kawakita, Aya Shinomiya, Takashi Tamiya, Masaaki Tokuda, Richard F Keep, Tohru Yamamoto, Yasuhiro Kuroda
• Journal: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association (J Stroke Cerebrovasc Dis) Vol. 25 Issue 9 Pg. 2184-8 (Sep 2016) ISSN: 1532-8511 [Electronic] United States
• PMID: 27342700 (Publication Type: Journal Article)
• Copyright: Copyright © 2016 National Stroke Association. Published by Elsevier Inc. All rights reserved.

Chemical References

• Blood Glucose
• Cytokines
• Sweetening Agents
• allose
• 8-Hydroxy-2'-Deoxyguanosine
• Deoxyguanosine
• Glucose

Topics

• 8-Hydroxy-2'-Deoxyguanosine
• Analysis of Variance
• Animals
• Blood Glucose (drug effects)
• Blood Pressure (drug effects)
• Cytokines (metabolism)
• Deoxyguanosine (analogs & derivatives, metabolism)
• Disease Models, Animal
• Dose-Response Relationship, Drug
• Gene Expression Regulation (drug effects)
• Gerbillinae
• Glucose (therapeutic use)
• Hippocampus (drug effects, metabolism)
• Male
• Maze Learning (drug effects)
• Movement Disorders (drug therapy, etiology)
• Reperfusion Injury (complications, drug therapy, metabolism)
• Sweetening Agents (therapeutic use)
• Time Factors