Feasibility and Safety of Hydrogen Gas Inhalation for Post-Cardiac Arrest Syndrome　- First-in-Human Pilot Study.

Abstract

BACKGROUND:

Hydrogen gas inhalation (HI) ameliorates cerebral and cardiac dysfunction in animal models of post-cardiac arrest syndrome (PCAS). HI for human patients with PCAS has never been studied.

METHODS AND RESULTS:

Between January 2014 and January 2015, 21 of 107 patients with out-of-hospital cardiac arrest achieved spontaneous return of circulation. After excluding 16 patients with specific criteria, 5 patients underwent HI together with target temperature management (TTM). No undesirable effects attributable to HI were observed and 4 patients survived 90 days with a favorable neurological outcome.

CONCLUSIONS:

HI in combination with TTM is a feasible therapy for patients with PCAS. (Circ J 2016; 80: 1870-1873).

• Authors: Tomoyoshi Tamura, Kei Hayashida, Motoaki Sano, Masaru Suzuki, Takayuki Shibusawa, Joe Yoshizawa, Yosuke Kobayashi, Takeshi Suzuki, Shigeo Ohta, Hiroshi Morisaki, Keiichi Fukuda, Shingo Hori
• Journal: Circulation journal : official journal of the Japanese Circulation Society (Circ J) Vol. 80 Issue 8 Pg. 1870-3 (Jul 25 2016) ISSN: 1347-4820 [Electronic] Japan
• PMID: 27334126 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Hydrogen

Topics

• Aged
• Female
• Heart Arrest (physiopathology, therapy)
• Humans
• Hydrogen (administration & dosage, adverse effects)
• Male
• Middle Aged
• Pilot Projects
• Prospective Studies