Abstract | OBJECTIVE: METHODS: Factors associated with the obliteration rate and neurologic complications were studied retrospectively in pediatric patients who underwent LINAC-based SRS for AVM between June 1995 and May 2014. RESULTS: The study cohort comprised 36 males and 33 females, with a median age at the time of SRS of 14 years (range, 7-18 years). The mean AVM volume was 8.5 ± 8.7 cc (range, 0.6-41.8 cc). The median marginal dose of radiation delivered was 15 Gy (range, 9-20 Gy). Magnetic resonance imaging (MRI) demonstrated complete obliteration of the AVM in 44 of the 69 patients (63.8%), at a mean follow up of 27.5 months (range, 12-90 months). On subgroup analysis, 41 of the 53 AVMs of ≤14 cc in volume (77.3%) were obliterated. AVMs with a modified AVM radiosurgery score <1 had significantly shorter obliteration times from the time of SRS (P = .006). On multivariate analysis, the mean marginal dose of radiation delivered to the AVM was the sole significant predictor of obliteration (odds ratio, 1.6; 95% confidence interval, 1 to 2.4). CONCLUSIONS: A modest median marginal dose of 15 Gy (16 Gy in the obliterated AVM group vs. 12 Gy in the nonobliterated group) resulted in an obliteration rate of 66.7% after LINAC-based SRS for intracranial AVM, with low rate.
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Authors | Vedantam Rajshekhar, Ranjith K Moorthy, Visalakshi Jeyaseelan, Subhashini John, Faith Rangad, P N Viswanathan, Paul Ravindran, Rabiraja Singh |
Journal | World neurosurgery
(World Neurosurg)
Vol. 95
Pg. 425-433
(Nov 2016)
ISSN: 1878-8769 [Electronic] United States |
PMID | 27302562
(Publication Type: Journal Article)
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Copyright | Copyright © 2016 Elsevier Inc. All rights reserved. |
Topics |
- Adolescent
- Angiography, Digital Subtraction
- Cerebral Angiography
- Child
- Cohort Studies
- Female
- Humans
- Intracranial Arteriovenous Malformations
(diagnostic imaging, radiotherapy)
- Magnetic Resonance Imaging
- Male
- Particle Accelerators
- Radiosurgery
(methods)
- Radiotherapy Dosage
- Retrospective Studies
- Treatment Outcome
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