The Human Antimicrobial Protein Bactericidal/Permeability-Increasing Protein (BPI) Inhibits the Infectivity of Influenza A Virus.

Abstract

In addition to their well-known antibacterial activity some antimicrobial peptides and proteins (AMPs) display also antiviral effects. A 27 aa peptide from the N-terminal part of human bactericidal/permeability-increasing protein (BPI) previously shown to harbour antibacterial activity inhibits the infectivity of multiple Influenza A virus strains (H1N1, H3N2 and H5N1) the causing agent of the Influenza pneumonia. In contrast, the homologous murine BPI-peptide did not show activity against Influenza A virus. In addition human BPI-peptide inhibits the activation of immune cells mediated by Influenza A virus. By changing the human BPI-peptide to the sequence of the mouse homologous peptide the antiviral activity was completely abolished. Furthermore, the human BPI-peptide also inhibited the pathogenicity of the Vesicular Stomatitis Virus but failed to interfere with HIV and measles virus. Electron microscopy indicate that the human BPI-peptide interferes with the virus envelope and at high concentrations was able to destroy the particles completely.

• Authors: Olaf Pinkenburg, Torben Meyer, Norbert Bannert, Steven Norley, Kathrin Bolte, Volker Czudai-Matwich, Susanne Herold, André Gessner, Markus Schnare
• Journal: PloS one (PLoS One) Vol. 11 Issue 6 Pg. e0156929 ( 2016) ISSN: 1932-6203 [Electronic] United States
• PMID: 27273104 (Publication Type: Journal Article)

Chemical References

• Antimicrobial Cationic Peptides
• Antiviral Agents
• Blood Proteins
• Peptide Fragments
• bactericidal permeability increasing protein

Topics

• Animals
• Antimicrobial Cationic Peptides (metabolism, pharmacology)
• Antiviral Agents (metabolism, pharmacology)
• Blood Proteins (metabolism, pharmacology)
• Cells, Cultured
• Cricetinae
• Dogs
• Humans
• Influenza A Virus, H1N1 Subtype (drug effects, pathogenicity)
• Influenza A Virus, H3N2 Subtype (drug effects, pathogenicity)
• Influenza A Virus, H5N1 Subtype (drug effects, pathogenicity)
• Influenza A virus (drug effects, pathogenicity)
• Madin Darby Canine Kidney Cells
• Neutrophils (metabolism)
• Peptide Fragments (pharmacology)
• Virus Replication (drug effects)