Longitudinal comparison of femtosecond-assisted sub-Bowman keratomileusis versus photorefractive keratectomy for high myopia.

Abstract

PURPOSE:

To longitudinally compare the visual and refractive outcomes and changes in corneal thickness between femtosecond-assisted sub-Bowmen keratomileusis (SBK) and photorefractive keratectomy (PRK) with mitomycin C in eyes with high myopia.

METHODS:

Patients with spherical equivalent ≥6 dioptres (D) who underwent femtosecond-assisted SBK or PRK with mitomycin C were recruited. All patients were examined preoperatively and after 1 week, and, 1, 3, 6 and 12 months postoperatively. Assessments included uncorrected and best-corrected distance visual acuity , and manifest refraction spherical equivalent. Corneal thickness was measured using swept source optical coherence tomography.

RESULTS:

A total of 110 eyes were included (68 PRK, 42 SBK). Change in efficacy index and safety index was not significantly different between both groups beyond 1 week postoperatively (p≥0.116). Manifest refraction spherical equivalent changed significantly from -9.02±1.92 D preoperatively to -0.21±0.31 D and from -8.25±1.10 D preoperatively to -0.53±0.55 D at 1 year after PRK and SBK, respectively (p<0.0001). The variance of postoperative refraction was significantly smaller after PRK throughout the 1-year follow-up compared with SBK (p≤0.0024). The central corneal thickness stabilised at 1 week after PRK and 3 months after SBK.

CONCLUSIONS:

Our study showed that femtosecond-assisted SBK and PRK with mitomycin C have comparable safety and efficacy for correction of high myopia. However, better predictability of postoperative refraction was noted after PRK compared with SBK.

• Authors: Tommy C Y Chan, Marco C Y Yu, Sammie Mak, Vishal Jhanji
• Journal: The British journal of ophthalmology (Br J Ophthalmol) Vol. 101 Issue 3 Pg. 275-282 (03 2017) ISSN: 1468-2079 [Electronic] England
• PMID: 27267450 (Publication Type: Comparative Study, Journal Article)
• Copyright: Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Chemical References

• Mitomycin

Topics

• Adult
• Analysis of Variance
• Cornea (surgery)
• Female
• Humans
• Keratomileusis, Laser In Situ (methods)
• Lasers, Excimer (therapeutic use)
• Longitudinal Studies
• Male
• Middle Aged
• Mitomycin (administration & dosage)
• Myopia (surgery)
• Photorefractive Keratectomy (methods)
• Refraction, Ocular
• Visual Acuity
• Young Adult