Abstract | BACKGROUND: METHODS: Six patients with DAH were treated with intrapulmonary instillation of rFVIIa. Doses were divided equally between the right and the left lungs. Doses were 30, 50, or 60 mcg/kg and frequencies varied from a single administration to repeated doses on subsequent days on the basis of the clinical response. All patients received high-dose steroids, and 4 also received an aminocaproic acid infusion. RESULTS: Intrapulmonary rVFIIa treated DAH effectively in 5 of 6 patients. Doses used were smaller and less frequent than those described previously. CONCLUSIONS: Intrapulmonary factor VII is an effective adjunctive treatment for DAH. We achieved treatment success with both smaller and less frequent doses than those described previously. This may be a good therapeutic option for DAH, particularly when standard therapies have failed or bleeding is immediately life threatening. It is possible that intrapulmonary rFVIIa could save costs, while improving the intensive care unit length of stay. Further prospective studies are needed to assess the optimal dose and frequency for adequate therapeutic efficacy.
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Authors | Mary S Baker, Khalil J Diab, W Graham Carlos, Praveen Mathur |
Journal | Journal of bronchology & interventional pulmonology
(J Bronchology Interv Pulmonol)
Vol. 23
Issue 3
Pg. 255-8
(Jul 2016)
ISSN: 1948-8270 [Electronic] United States |
PMID | 27261934
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Recombinant Proteins
- recombinant FVIIa
- Factor VIIa
- Aminocaproic Acid
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Topics |
- Aged
- Aged, 80 and over
- Aminocaproic Acid
(administration & dosage, therapeutic use)
- Drug Therapy, Combination
- Factor VIIa
(administration & dosage, therapeutic use)
- Fatal Outcome
- Female
- Hemorrhage
(drug therapy, etiology)
- Humans
- Instillation, Drug
- Lung Diseases
(drug therapy, etiology)
- Male
- Middle Aged
- Prospective Studies
- Pulmonary Alveoli
(pathology)
- Recombinant Proteins
(administration & dosage, therapeutic use)
- Treatment Outcome
- Young Adult
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