Frequency of Tabagism and N34S and P55S Mutations of Serine Peptidase Inhibitor, Kazal Type 1 (SPINK1) and R254W Mutation of Chymotrypsin C (CTRC) in Patients With Chronic Pancreatitis and Controls.

Abstract

OBJECTIVE:

This study aimed to investigate the association between chronic pancreatitis and smoking or genetic mutations.

METHODS:

The study sample comprised 148 patients with chronic pancreatitis, 110 chronic alcoholic subjects without pancreatic disease, and 297 volunteer blood donors.

RESULTS:

Of the patients with chronic pancreatitis, 74% had alcoholic etiology and 26% had idiopathic pancreatitis. The frequency of smoking was 91.4% in patients with alcoholic pancreatitis, higher than 73.3% in alcoholic subjects without pancreatitis (P < 0.01). The difference in smoking frequency was not significant between the patients with idiopathic pancreatitis and blood donors. The N34S mutation of serine peptidase inhibitor, Kazal type 1 (SPINK1) was found in 2.7% of patients with chronic alcoholic pancreatitis, in 5.3% of patients with idiopathic pancreatitis, and in 0.4% of blood donors (P = 0.02). The P55S mutation of SPINK1 was found in 2.7% of patients with alcoholic pancreatitis and in 0.7% of blood donors (P = 0.12). The R254W mutation of chymotrypsin C was found in 0.9% of patients with alcoholic pancreatitis, in 0.9% of chronic alcoholic subjects without pancreatitis, and in 0.4% of blood donors (P = 0.75). In all cases, the mutations were heterozygous.

CONCLUSIONS:

Smoking and the N34S mutation of SPINK1 were positively correlated with chronic pancreatitis.

• Authors: Marianges Zadrozny Gouvêa da Costa, Júlia Glória Lucatelli Pires, Paulo Dominguez Nasser, Camila da Silva Ferreira, Ana Cristina de Sá Teixeira, Denise Cerqueira Paranaguá-Vezozzo, Dulce Reis Guarita, Flair José Carrilho, Suzane Kioko Ono
• Journal: Pancreas (Pancreas) Vol. 45 Issue 9 Pg. 1330-5 (10 2016) ISSN: 1536-4828 [Electronic] United States
• PMID: 27253233 (Publication Type: Journal Article)

Chemical References

• Serine
• Trypsin Inhibitor, Kazal Pancreatic
• Chymotrypsin
• chymotrypsin C

Topics

• Chronic Disease
• Chymotrypsin
• Genetic Predisposition to Disease
• Humans
• Mutation
• Pancreatitis
• Serine
• Trypsin Inhibitor, Kazal Pancreatic