Antibodies to myelin basic protein are associated with cognitive decline after stroke.

Abstract

B lymphocytes cause post-stroke cognitive decline in mice. We therefore evaluated the association between autoantibodies and post-stroke cognitive decline in a prospectively collected human cohort. The mini-mental state exam (MMSE) was administered 30, 90, 180, and 365days after stroke. Antibody titers to myelin basic protein (MBP), proteolipid protein, and several non-specific proteins were determined. Among 58 subjects with initial MMSE≥20 and at least 2 MMSE examinations in the year after stroke, cognitive decline (MMSE decrease ≥2) occurred in 10 (17%) subjects. In multivariate analysis, MBP antibody titers were the only independent predictor of cognitive decline (OR=9.02 [1.18, 68.90]; P=0.03).

• Authors: Kyra J Becker, Patricia Tanzi, Dannielle Zierath, Marion S Buckwalter
• Journal: Journal of neuroimmunology (J Neuroimmunol) Vol. 295-296 Pg. 9-11 (06 15 2016) ISSN: 1872-8421 [Electronic] Netherlands
• PMID: 27235342 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
• Copyright: Copyright © 2016 Elsevier B.V. All rights reserved.

Chemical References

• Autoantibodies
• Myelin Basic Protein
• Myelin Proteolipid Protein
• PLP1 protein, human

Topics

• Adult
• Aged
• Autoantibodies (metabolism)
• Cognition Disorders (etiology, immunology)
• Cohort Studies
• Female
• Gene Expression Regulation (physiology)
• Humans
• Male
• Mental Status Schedule
• Middle Aged
• Myelin Basic Protein (immunology)
• Myelin Proteolipid Protein (immunology)
• Neuropsychological Tests
• Stroke (complications)