Effects of resuscitation with polymerized porcine hemoglobin (pPolyHb) on hemodynamic stability and oxygen delivery in a rat model of hemorrhagic shock.

Abstract	The objective of this study was to evaluate the effects of polymerized porcine hemoglobin (pPolyHb) on hemodynamic stability and oxygen delivery in a rat model of hemorrhagic shock. Rats underwent controlled hemorrhage, resulting in the loss of 65% of their blood volume in 90 minutes. The results showed that pPolyHb was superior to hetastarch and saline, and similar to whole blood, in restoring hemodynamic stability and reversing anaerobic metabolism caused by hemorrhage. Furthermore, pPolyHb improved oxygen supply and increased blood oxygen content. These data suggest that pPolyHb can be effective in improving tissue perfusion under conditions of severe hemorrhagic shock.
Authors	Li Wang, Fang Liu, Kunping Yan, Wencan Pan, Lijuan Xu, Huifang Liu, Chengbin Yan, Chao Chen, Hongli Zhu
Journal	Artificial cells, nanomedicine, and biotechnology (Artif Cells Nanomed Biotechnol) Vol. 45 Issue 1 Pg. 51-57 (Feb 2017) ISSN: 2169-141X [Electronic] England
PMID	27225986 (Publication Type: Journal Article)
Chemical References	Blood Substitutes Hemoglobins polyhemoglobin Oxygen
Topics	Animals Blood Substitutes (pharmacology) Disease Models, Animal Hemodynamics (drug effects) Hemoglobins (pharmacology) Male Oxygen (blood) Rats Rats, Sprague-Dawley Resuscitation (methods) Shock, Hemorrhagic (blood, drug therapy) Swine

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