Abstract | BACKGROUND: METHODS: The authors describe a unique pathologic condition, where significant Le Fort type trauma was associated with subsequent development of granulomatosis with polyangiitis and malignant pyoderma. Successive operations to excise necrotic tissue and reconstruct the defects were followed by worsening inflammation and tissue erosions. Trauma and surgery in proximity to the eye and sinuses masked the initial clinical presentation and led to delay in diagnosis and disease progression. The resultant facial disfigurement and tissue loss were substantial. RESULTS: CONCLUSION: Recognition of this rare pathologic association is essential, to prevent delays in diagnosis and treatment that can lead to major craniofacial tissue loss. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, V.
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Authors | Brian Gastman, Ahmed M Hashem, Risal Djohan, Steven Bernard, Mark Hendrickson, Graham Schwarz, Bahar B Gharb, Antonio Rampazzo, Anthony Fernandez, James Zins, Gary S Hoffman, Gaby Doumit, Maria Siemionow, Francis Papay |
Journal | Plastic and reconstructive surgery
(Plast Reconstr Surg)
Vol. 137
Issue 6
Pg. 1007e-1015e
(Jun 2016)
ISSN: 1529-4242 [Electronic] United States |
PMID | 27219252
(Publication Type: Case Reports, Journal Article)
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Topics |
- Adult
- Allografts
- Combined Modality Therapy
- Composite Tissue Allografts
(surgery)
- Debridement
- Diagnosis, Differential
- Disease Progression
- Facial Transplantation
(methods)
- Follow-Up Studies
- Granulomatosis with Polyangiitis
(diagnosis, surgery)
- Humans
- Male
- Maxillary Fractures
(complications, diagnosis, surgery)
- Microdialysis
- Postoperative Complications
(diagnosis, surgery)
- Pyoderma
(surgery)
- Reoperation
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