Oxygen Monitoring Reduces the Risk for Retinopathy of Prematurity in a Mexican Population.

Abstract

BACKGROUND:

Retinopathy of prematurity (ROP), a potentially blinding disease, affects preterm infants. High levels of oxygen saturation are a well-known risk factor for ROP.

OBJECTIVES:

To assess the frequency of ROP type 1 needing treatment after improved oxygen monitoring (2011) in a Mexican preterm population selected for WINROP analyses and to retrospectively revalidate WINROP, an online surveillance system identifying infants at risk of developing ROP type 1.

METHODS:

Preterm infants born with birth weight (BW) <1,750 g and/or at gestational age (GA) ≤34 weeks, screened for ROP in 2012-2014 at the Hospital Civil de Guadalajara, Mexico were included (n = 151). Eighty-five infants with GA <32 weeks qualified for WINROP analyses. GA, BW, maximal ROP stage, ROP treatment and weekly weights were recorded. The results in the present study were compared to those of a previous WINROP study in the same hospital (2005-2010; n = 352).

RESULTS:

In the present WINROP cohort, 11.8% of the infants born at GA <32 weeks received treatment compared to 51.0% of the infants in the previous WINROP cohort. One infant (3%) born at GA ≥32 weeks received treatment during the present study period compared to 35.6% during the previous period. WINROP displayed 80.0% sensitivity in infants born at GA <32 weeks in the present study compared to 84.7% in the previous study.

CONCLUSIONS:

Uncontrolled oxygen supplementation is the major risk factor for severe ROP in infants born at GA ≥32 weeks. After improved oxygen monitoring, the frequency of ROP treatment was dramatically reduced at the Hospital Civil de Guadalajara, Mexico.

• Authors: Luz Consuelo Zepeda-Romero, Pia Lundgren, Jose Alfonso Gutierrez-Padilla, Larissa Maria Gomez-Ruiz, Moises Quiles Corona, José Víctor Orozco-Monroy, Andrea Barragan-Sánchez, Juan Carlos Razo-Cervantes, Chatarina Löfqvist, Anna-Lena Hård, Ann Hellström
• Journal: Neonatology (Neonatology) Vol. 110 Issue 2 Pg. 135-40 ( 2016) ISSN: 1661-7819 [Electronic] Switzerland
• PMID: 27088589 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2016 S. Karger AG, Basel.

Chemical References

• Oxygen

Topics

• Algorithms
• Gestational Age
• Humans
• Infant, Extremely Premature
• Infant, Newborn
• Infant, Very Low Birth Weight
• Intensive Care Units, Neonatal
• Male
• Mexico (epidemiology)
• Neonatal Screening
• Oxygen (adverse effects, therapeutic use)
• Retinopathy of Prematurity (epidemiology, prevention & control)
• Retrospective Studies
• Risk Factors