Airway bacteria drive a progressive COPD-like phenotype in mice with polymeric immunoglobulin receptor deficiency.
Abstract |
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Authors | Bradley W Richmond, Robert M Brucker, Wei Han, Rui-Hong Du, Yongqin Zhang, Dong-Sheng Cheng, Linda Gleaves, Rasul Abdolrasulnia, Dina Polosukhina, Peter E Clark, Seth R Bordenstein, Timothy S Blackwell, Vasiliy V Polosukhin |
Journal | Nature communications
(Nat Commun)
Vol. 7
Pg. 11240
(Apr 05 2016)
ISSN: 2041-1723 [Electronic] England |
PMID | 27046438
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Aminopyridines
- Benzamides
- Cyclopropanes
- Immunoglobulin A, Secretory
- NF-kappa B
- Phosphodiesterase 4 Inhibitors
- Receptors, Polymeric Immunoglobulin
- Roflumilast
- Cyclic Nucleotide Phosphodiesterases, Type 4
- Leukocyte Elastase
- Matrix Metalloproteinase 12
- matrix metallopeptidase 12, mouse
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Topics |
- Aging
(immunology, pathology)
- Airway Remodeling
(immunology)
- Aminopyridines
(pharmacology)
- Animals
- Benzamides
(pharmacology)
- Cyclic Nucleotide Phosphodiesterases, Type 4
(genetics, immunology)
- Cyclopropanes
(pharmacology)
- Disease Models, Animal
- Gene Expression Regulation
- Host-Pathogen Interactions
- Humans
- Immunity, Innate
- Immunoglobulin A, Secretory
(genetics)
- Leukocyte Elastase
(genetics, immunology)
- Lung
(drug effects, immunology, microbiology, pathology)
- Matrix Metalloproteinase 12
(genetics, immunology)
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Microbiota
(immunology)
- NF-kappa B
(genetics, immunology)
- Phosphodiesterase 4 Inhibitors
(pharmacology)
- Pulmonary Disease, Chronic Obstructive
(drug therapy, genetics, immunology, microbiology)
- Pulmonary Emphysema
(drug therapy, genetics, immunology, microbiology)
- Receptors, Polymeric Immunoglobulin
(deficiency, genetics, immunology)
- Respiratory Mucosa
(drug effects, immunology, microbiology, pathology)
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