Abstract | AIMS: The possible link between hyperglycaemia-induced oxidative stress (OxS) and diabetic complications is suggested by many in vitro studies. However, not much attention has been paid to the clinical evidence supporting this hypothesis, as well as to their possible therapeutic implications. DATA SYNTHESIS: Some prospective studies show a direct correlation between an increase in OxS biomarkers and the appearance of diabetes complications. This is consistent with the evidence that any acute increase of glycaemia, particularly post-prandial, and hypoglycaemia causes endothelial dysfunction and inflammation, through the generation of an OxS. However, the detection of free radicals is difficult as they are highly reactive molecules with a short half-life. Instead, the metabolites of OxS are measured. Interventional trials with supplemented antioxidants have failed to show any beneficial effects. Conversely, natural foods show very promising results. CONCLUSIONS:
|
Authors | A Ceriello, R Testa, S Genovese |
Journal | Nutrition, metabolism, and cardiovascular diseases : NMCD
(Nutr Metab Cardiovasc Dis)
Vol. 26
Issue 4
Pg. 285-92
(Apr 2016)
ISSN: 1590-3729 [Electronic] Netherlands |
PMID | 27036849
(Publication Type: Journal Article, Review)
|
Copyright | Copyright © 2016 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved. |
Chemical References |
- Antioxidants
- Biomarkers
- Hypoglycemic Agents
- Reactive Oxygen Species
|
Topics |
- Antioxidants
(pharmacology)
- Biomarkers
(blood)
- Cardiovascular Diseases
(blood, drug therapy)
- Diabetic Angiopathies
(blood, drug therapy)
- Diet, Mediterranean
- Drug Synergism
- Endothelium, Vascular
(physiopathology)
- Humans
- Hypoglycemic Agents
(pharmacology)
- Oxidative Stress
- Randomized Controlled Trials as Topic
- Reactive Oxygen Species
(metabolism)
|