Oral administration of lactulose: a novel therapy for acute carbon monoxide poisoning via increasing intestinal hydrogen production.

Abstract

It has been known that the pathophysiology of carbon monoxide (CO) poisoning is related to hypoxia, the increased production of reactive oxygen species (ROS) and oxidative stress. Studies have shown that the novel, safe and effective free radical scavenger, hydrogen, has neuroprotective effects in both acute CO poisoning and delayed neuropsychological sequelae in CO poisoning. Orally administered lactulose, which may be used by some intestinal bacteria as a food source to produce endogenous hydrogen, can ameliorate oxidative stress. Based on the available findings, we hypothesize that oral administration of lactulose may be a novel therapy for acute CO poisoning via increasing intestinal hydrogen production.

• Authors: Dan-Feng Fan, Hui-Jun Hu, Xue-Jun Sun, Xiang-En Meng, Yu Zhang, Shu-Yi Pan
• Journal: Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc (Undersea Hyperb Med) 2016 Jan-Feb Vol. 43 Issue 1 Pg. 45-8 ISSN: 1066-2936 [Print] United States
• PMID: 27000012 (Publication Type: Journal Article)

Chemical References

• Reactive Oxygen Species
• Lactulose
• Hydrogen

Topics

• Administration, Oral
• Carbon Monoxide Poisoning (therapy)
• Humans
• Hydrogen (metabolism)
• Intestinal Mucosa (metabolism)
• Lactulose (administration & dosage)
• Oxidative Stress
• Reactive Oxygen Species (metabolism)