The Protective Effects of Caffeic Acid Phenethyl Ester on Acetylsalicylic Acid-induced Lung Injury in Rats.

Abstract

AIM:

We aimed to investigate the protective effect of caffeic acid phenethyl ester (CAPE) on acetylsalicylic acid (ASA)-induced lung damage in rats in the present study.

METHODS:

A total of 40 rats were randomly divided into five groups, with eight rats in each group-group 1: control, not receiving any medication; group 2: ASA (50 mg/kg/day); group 3: ASA (50 mg/kg/day) plus CAPE (20 μg/kg/day); group 4: ASA (100 mg/kg/day); and group 5: ASA (100 mg/kg/day) plus CAPE (20 μg/kg/day). ASA and CAPE were given via orogastric gavage for 5 days. The total oxidant status (TOS), total antioxidant capacity (TAC), oxidant stress index (OSI), and paraoxonase-1 (PON-1) activity of the blood samples and lung tissues were determined. Histopathological examinations of the lung tissues were performed by using light microscopic methods.

RESULTS:

CAPE treatment significantly increased antioxidant PON-1 level both in the lung tissue and plasma (p < .05). Plasma antioxidant marker (TAC, PON-1) levels significantly increased and oxidant marker (TOS, OSI) levels significantly decreased in CAPE-treated rats (groups 3,5) compared to ASA given no-CAPE groups (group 2,4) (p < .05). Treatment with CAPE improved pulmonary interstitial inflammation and eosinophil accumulation due to ASA histopathologically.

CONCLUSION:

Eosinophil-rich inflammation and oxidative stress play important roles in ASA-induced lung toxicity, and CAPE may protect against ASA-induced lung toxicity by reduction of oxidative damage and inflammation in rats.

• Authors: Mahşuk Taylan, Halide Kaya, Melike Demir, Osman Evliyaoğlu, Hadice Selimoglu Sen, Ugur Fırat, Aysenur Keles, Sureyya Yilmaz, Cengizhan Sezgi
• Journal: Journal of investigative surgery : the official journal of the Academy of Surgical Research (J Invest Surg) Vol. 29 Issue 6 Pg. 328-334 (Dec 2016) ISSN: 1521-0553 [Electronic] United States
• PMID: 26980558 (Publication Type: Journal Article)

Chemical References

• Caffeic Acids
• caffeic acid phenethyl ester
• Phenylethyl Alcohol
• Aspirin

Topics

• Animals
• Aspirin
• Caffeic Acids (pharmacology, therapeutic use)
• Drug Evaluation, Preclinical
• Female
• Lung (pathology)
• Lung Injury (chemically induced, pathology, prevention & control)
• Oxidative Stress (drug effects)
• Phenylethyl Alcohol (analogs & derivatives, pharmacology, therapeutic use)
• Random Allocation
• Rats, Wistar