[A comparative analysis of the efficacy of neuromidin and galantamine in Alzheimer's disease].

Abstract

OBJECTIVE:

To evaluate the cognitive changes in patients with mild to moderate Alzheimer's disease after the treatment with acetylcholinesterase inhibitors - neuromidin and galantamine.

MATERIAL AND METHODS:

Fifty-eight patients with probable Alzheimer's disease, aged 60-84 years (mean 73.2±6.7), were enrolled in a 20-week double-blind parallel group study. All patients were randomized in 2 groups: group 1 (n=28) received neuromidin, group 2 (n=30) - galantamine. Treatment efficacy was evaluated with the ADAS-cog/11 scale.

RESULTS:

Both drugs significantly improved or stabilized cognitive function in the patients. The most marked changes were obtained in the group of patients treated with neuromidin (р<0.05).

CONCLUSION:

The results suggest that the effectiveness of anticholinesterase treatment of Alzheimer's disease could be determined not only by the central but also peripheral cholinergic action.

• Authors: S A Zhivolupov, N A Rashidov, I N Samartsev, E V Jakovlev
• Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (Zh Nevrol Psikhiatr Im S S Korsakova) 2015 Vol. 115 Issue 10 Pt 2 Pg. 22-27 ISSN: 1997-7298 [Print] Russia (Federation)
• Vernacular Title: Sravnitel'nyi analiz effektivnosti neiromidina i galantamina pri bolezni Al'tsgeimera.
• PMID: 26977912 (Publication Type: English Abstract, Journal Article)