Vitamin D Status in Chronic Kidney Disease - UVB Irradiation Is Superior to Oral Supplementation.

Abstract

BACKGROUND:

In chronic kidney disease (CKD) a deficiency of 1,25-dihydroxyvitamin D is common. The aim of this review was to compare vitamin D status after oral supplementation of vitamin D3 to that of serial suberythemal irradiation in end-stage kidney disease (ESKD) patients.

PATIENTS AND METHODS:

Ninety-five patients, with a mean age of 62 (range=35-82) years, were treated with a mean dose of 35,000 (20,000-60,000) IU vitamin D3 per week for a period of 18 months. Fourteen patients, with a mean age of 51 (range=41-57) years, were whole-body UVB irradiated for over 6 months. From 3 hemodialysis patients skin biopsies were performed.

RESULTS:

With oral supplementation 25(OH)D3 increased by 60%. With UV irradiation 25(OH)D3 increased by 400%. Gene expression analysis demonstrated an improvement in the vitamin D receptor (VDR) by 0.65 fold, in 1-alpha-hydroxylase (CYP27B1) by 1.0 fold, and in 25-hydroxylase (CYP2R) by 1.2 fold.

CONCLUSION:

Serial suberythemal UVB irradiation of patients with CKD on dialysis is capable to improve serum 25(OH)D3 and 1,25(OH)2D3 by enhancing the skin's ability to activate vitamin D.

• Authors: Rolfdieter Krause, Heinz Jürgen Roth, Heinrich Kaase, Rainer Stange, Michael F Holick
• Journal: Anticancer research (Anticancer Res) Vol. 36 Issue 3 Pg. 1397-401 (Mar 2016) ISSN: 1791-7530 [Electronic] Greece
• PMID: 26977042 (Publication Type: Journal Article)
• Copyright: Copyright© 2016 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

Chemical References

• Receptors, Calcitriol
• Vitamin D
• Cholecalciferol
• 1,25-dihydroxyvitamin D
• Vitamin D3 24-Hydroxylase
• Calcitriol
• Calcifediol

Topics

• Adult
• Aged
• Aged, 80 and over
• Calcifediol (administration & dosage, blood, metabolism)
• Calcitriol (administration & dosage, blood, metabolism)
• Cholecalciferol (administration & dosage, blood, metabolism)
• Dietary Supplements
• Humans
• Kidney Failure, Chronic (blood, metabolism)
• Male
• Middle Aged
• Receptors, Calcitriol (metabolism)
• Renal Dialysis (methods)
• Renal Insufficiency, Chronic (blood, metabolism)
• Ultraviolet Rays
• Vitamin D (administration & dosage, analogs & derivatives, blood, metabolism)
• Vitamin D Deficiency (blood, drug therapy, metabolism)
• Vitamin D3 24-Hydroxylase (metabolism)