Abstract |
Computed tomography (CT), together with image analysis technologies, enable the construction of regional volume (VREG) and local transpulmonary pressure (PTP,REG) maps of the lung. Purpose of this study is to assess the distribution of VREG vs PTP,REG along the gravitational axis in healthy (HL) and experimental acute lung injury conditions (eALI) at various positive end-expiratory pressures (PEEPs) and inflation volumes. Mechanically ventilated pigs underwent inspiratory hold maneuvers at increasing volumes simultaneously with lung CT scans. eALI was induced via the iv administration of oleic acid. We computed voxel-level VREG vs PTP,REG curves into eleven isogravitational planes by applying polynomial regressions. Via F-test, we determined that VREG vs PTP,REG curves derived from different anatomical planes (p-values<1.4E-3), exposed to different PEEPs (p-values<1.5E-5) or subtending different lung status (p-values<3E-3) were statistically different (except for two cases of adjacent planes). Lung parenchyma exhibits different elastic behaviors based on its position and the density of superimposed tissue which can increase during lung injury.
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Authors | Mariangela Pellegrini, Savino Derosa, Angela Tannoia, Christian Rylander, Tommaso Fiore, Anders Larsson, Göran Hedenstierna, Gaetano Perchiazzi |
Journal | Respiratory physiology & neurobiology
(Respir Physiol Neurobiol)
Vol. 228
Pg. 16-24
(07 2016)
ISSN: 1878-1519 [Electronic] Netherlands |
PMID | 26976688
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2016 Elsevier B.V. All rights reserved. |
Chemical References |
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Topics |
- Acute Lung Injury
(diagnostic imaging, physiopathology)
- Animals
- Breath Holding
- Disease Models, Animal
- Elasticity
- Gravitation
- Hemodynamics
(physiology)
- Lung
(diagnostic imaging, pathology, physiopathology)
- Lung Compliance
- Lung Volume Measurements
- Models, Cardiovascular
- Oleic Acid
- Organ Size
- Pressure
- Pulmonary Gas Exchange
(physiology)
- Regression Analysis
- Respiration, Artificial
- Swine
- Tomography, X-Ray Computed
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