Abstract | BACKGROUND: METHODS: Using age, sex, and body mass index (BMI) adjusted linear regression, we examined 38 exposures (demographic and anthropometric measures, chronic disease history, NSAIDs, dietary factors, and supplement use) of 8 inflammation biomarkers [CRP, IL1β, IL6, IL8, TNFα, and soluble TNF receptors (sTNFR) in plasma; and prostaglandin E2 metabolite ( PGE-M) in urine] in 217 adults, ages 50 to 76 years. RESULTS: Increasing age was associated with higher concentrations of all biomarkers except IL1β. BMI was positively associated with CRP and sTNFR I and II. Saturated fat intake was associated with increased CRP, sTNFRII, TNFα, and IL1β, whereas eicosapentaenoic acid + docosahexaenoic acid (EPA+DHA) intake (diet or total) was associated with decreased CRP, TNFα, and IL1β. Results for sex were varied: CRP and IL6 were lower among men, whereas PGE-M and sTNFRI were higher. Higher CRP was also associated with smoking, hormone replacement therapy use, and γ- tocopherol intake; lower CRP with physical activity, and intakes of dietary vitamin C and total fiber. CONCLUSIONS: IMPACT:
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Authors | Sandi L Navarro, Elizabeth D Kantor, Xiaoling Song, Ginger L Milne, Johanna W Lampe, Mario Kratz, Emily White |
Journal | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
(Cancer Epidemiol Biomarkers Prev)
Vol. 25
Issue 3
Pg. 521-31
(Mar 2016)
ISSN: 1538-7755 [Electronic] United States |
PMID | 26908433
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Copyright | ©2016 American Association for Cancer Research. |
Chemical References |
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Topics |
- Aged
- Biomarkers
(blood)
- Cohort Studies
- Early Detection of Cancer
- Female
- Humans
- Inflammation
(blood)
- Male
- Middle Aged
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