Abstract | INTRODUCTION: METHODS: We examined cross-sectional associations of insulin sensitivity, inflammation, and liver synthetic function with VLDL particle (VLDL-P) concentration and size among 1,850 older adults in the Cardiovascular Health Study. RESULTS: Indices for high insulin sensitivity and low liver synthetic function were associated with lower concentrations of VLDL-P. In addition, insulin resistance preferentially increased concentration of large VLDL and was associated with mean VLDL size. Indices for inflammation however demonstrated a nonlinear relationship with both VLDL-P concentration and VLDL size. When mutually adjusted, one standard deviation (SD) increment in Matsuda index and C-reactive protein (CRP) were associated with 4.9 nmol/L (-8.2 to -1.5, p=0.005) and 6.3 nmol/L (-11.0 to -1.6, p=0.009) lower VLDL-P concentration respectively. In contrast, one-SD increment in factor VII, a marker for liver synthetic function, was associated with 16.9 nmol/L (12.6-21.2, p<0.001) higher VLDL-P concentration. Furthermore, a one-SD increment in the Matsuda index was associated with 1.1 nm (-2.0 to -0.3, p=0.006) smaller mean VLDL size, whereas CRP and factor VII were not associated with VLDL size. CONCLUSION:
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Authors | Z Gordon Jiang, Ian H de Boer, Rachel H Mackey, Majken K Jensen, Michelle Lai, Simon C Robson, Russell Tracy, Lewis H Kuller, Kenneth J Mukamal |
Journal | Metabolism: clinical and experimental
(Metabolism)
Vol. 65
Issue 3
Pg. 92-9
(Mar 2016)
ISSN: 1532-8600 [Electronic] United States |
PMID | 26892520
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Copyright | Copyright © 2015 Elsevier Inc. All rights reserved. |
Chemical References |
- Lipoproteins, VLDL
- Factor VII
- C-Reactive Protein
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Topics |
- Aged
- Aged, 80 and over
- C-Reactive Protein
(analysis)
- Cross-Sectional Studies
- Factor VII
(analysis)
- Female
- Humans
- Inflammation
(blood)
- Insulin Resistance
- Lipoproteins, VLDL
(blood)
- Liver
(metabolism)
- Liver Function Tests
- Male
- Risk Factors
- Socioeconomic Factors
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