Abstract | BACKGROUND: Results from the J-ROCKET AF study revealed that rivaroxaban was non-inferior to warfarin with respect to the principal safety outcomes in patients with non-valvular atrial fibrillation. This subgroup analysis evaluated whether non-major clinically relevant bleeding (NMCRB) could be a predictive factor for major bleeding (MB). Other predictive factors for MB were also obtained in both rivaroxaban and warfarin treatment groups. METHODS: The temporal incidence of MB was compared between the rivaroxaban and warfarin treatment groups. Assessment was made whether MB events were often preceded by NMCRB. Univariate and multivariate analyses were carried out to identify any independent predictive factors for MB in both treatment groups. RESULTS: CONCLUSIONS: Results from this subgroup analysis, particularly the fact that there was no repeated or sequential pattern between NMCRB and MB occurrences in both treatment groups, suggests that NMCRB might not be a predictive factor for MB. On the contrary, anemia and concomitant use of antiplatelet therapy were likely predictive factors for bleeding with warfarin and rivaroxaban treatment, respectively.
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Authors | Masatsugu Hori, Masayasu Matsumoto, Norio Tanahashi, Shin-Ichi Momomura, Shinichiro Uchiyama, Shinya Goto, Tohru Izumi, Yukihiro Koretsune, Mariko Kajikawa, Masaharu Kato, Mary Cavaliere, Kazuma Iekushi, Satoshi Yamanaka, J-ROCKET AF Study Investigators |
Journal | Journal of cardiology
(J Cardiol)
Vol. 68
Issue 6
Pg. 523-528
(12 2016)
ISSN: 1876-4738 [Electronic] Netherlands |
PMID | 26796348
(Publication Type: Journal Article)
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Copyright | Copyright © 2016 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved. |
Chemical References |
- Anticoagulants
- Platelet Aggregation Inhibitors
- Warfarin
- Rivaroxaban
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Topics |
- Aged
- Anemia
(complications)
- Anticoagulants
(administration & dosage, adverse effects)
- Atrial Fibrillation
(drug therapy)
- Female
- Hemorrhage
(chemically induced)
- Humans
- Japan
- Male
- Multivariate Analysis
- Platelet Aggregation Inhibitors
(adverse effects)
- Randomized Controlled Trials as Topic
- Rivaroxaban
(administration & dosage, adverse effects)
- Stroke
(prevention & control)
- Warfarin
(administration & dosage, adverse effects)
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