Effects of chronic administration of adipokinetic and hypertrehalosemic hormone on animal behavior, BDNF, and CREB expression in the hippocampus and neurogenesis in mice.

Abstract

Neurosecretory cells in corpus cardiacum of insects synthesize a set of hormones that are called adipokinetic, hypertrehalosaemic or hyperprolinaemic, depending on insect in question. This study investigated effects of chronic administration of Anax imperator adipokinetic hormone (Ani-AKH), Libellula auripennis adipokinetic hormone (Lia-AKH), and Phormia-Terra hypertrehalosaemic hormone (Pht-HrTH) on depression, anxiety, analgesy, locomotion in forced swimming (FST), elevated plus-maze (EPM), hot plate, and locomotor activity tests. Ani-AKH (1 and 2 mg/kg), Lia-AKH (1 and 2 mg/kg), and Pht-HrTH (1 and 2 mg/kg) had antidepressant effects in forced swimming test. Lia-AKH (2 mg/kg) and Pht-HrTH (1 and 2 mg/kg) had anxiolytic effects when given chronically in elevated plus-maze test. Ani-AKH (1 and 2 mg/kg) and Pht-HrTH (2 mg/kg) had antinociceptive effects in hot plate test in male balb-c mice. Ani-AKH (2 mg/kg), Lia-AKH (1 and 2 mg/kg), and Pht-HrTH had locomotion-enhancing effects in locomotor activity test in male balb-c mice. Drug treatment significantly increased brain-derived neurotrophic factor (BDNF) and cyclic adenosine monophosphate (cAMP) response element binding protein (CREB) gene expression levels compared to control levels. Pht-HrTH and Ani-AKH groups had significantly increased numbers of BrdU-labeled cells, while neurodegeneration was lower in the Pht-HrTH group. Our study showed that AKH/RPCH family peptides may be used in treatment of psychiatric illness such as depression and anxiety, in treatment of pain and in diseases related to locomotion system. AKH/RPCH family peptides increase neurotrophic factors in brain and have potential proliferative and neuroprotective effects in hippocampal neurogenesis and neurodegeneration.

• Authors: Oguz Mutlu, Esen Gumuslu, Sibel Kokturk, Guner Ulak, Furuzan Akar, Faruk Erden, Havva Kaya, Pelin Tanyeri
• Journal: Fundamental & clinical pharmacology (Fundam Clin Pharmacol) Vol. 30 Issue 1 Pg. 4-13 (Feb 2016) ISSN: 1472-8206 [Electronic] England
• PMID: 26791996 (Publication Type: Journal Article)
• Copyright: © 2015 Société Française de Pharmacologie et de Thérapeutique.

Chemical References

• Analgesics
• Anti-Anxiety Agents
• Brain-Derived Neurotrophic Factor
• Creb1 protein, mouse
• Cyclic AMP Response Element-Binding Protein
• Insect Hormones
• Neuropeptides
• Neuroprotective Agents
• Oligopeptides
• adipokinetic hormone
• hypertrehalosemic hormone
• Pyrrolidonecarboxylic Acid

Topics

• Analgesics (isolation & purification, pharmacology)
• Animals
• Anti-Anxiety Agents (isolation & purification, pharmacology)
• Behavior, Animal (drug effects)
• Brain-Derived Neurotrophic Factor (genetics)
• Cyclic AMP Response Element-Binding Protein (genetics)
• Hippocampus (drug effects, metabolism)
• Insect Hormones (isolation & purification, pharmacology)
• Maze Learning (drug effects)
• Mice, Inbred Strains
• Motor Activity (drug effects)
• Neurogenesis (drug effects)
• Neuropeptides (isolation & purification, pharmacology)
• Neuroprotective Agents (isolation & purification, pharmacology)
• Oligopeptides (isolation & purification, pharmacology)
• Pyrrolidonecarboxylic Acid (analogs & derivatives, isolation & purification, pharmacology)
• Swimming