Acute improvement of pulmonary hemodynamics does not alleviate Cheyne-Stokes respiration in chronic heart failure-a randomized, controlled, double-blind, crossover trial.

Abstract

OBJECTIVES:

This randomized, controlled trial aimed to investigate whether acute improvement of pulmonary congestion would reduce the severity of Cheyne-Stokes respiration (CSR) in patients with chronic heart failure (CHF).

METHODS:

Twenty-one consecutive patients with CHF and CSR (apnea-hypopnea index [AHI] ≥15/h) underwent right heart catheterization with titration of intravenous (IV) glyceryltrinitrate (GTN) to a maximum tolerable dosage and inhalation of iloprost 10 μg/mL after a washout phase. Maximum tolerable dosages of GTN and iloprost were randomly applied during full cardiorespiratory polysomnography within two split-night procedures and compared with IV or inhaled sodium chloride (NaCl) 0.9 %, respectively.

RESULTS:

GTN (6.2 ± 1.5 mg/h) and iloprost significantly lowered \mean pulmonary artery pressure (20.1 ± 9.0 to 11.6 ± 4.2 mmHg, p < 0.001 and 16.9 ± 7.9 to 14.2 ± 6.4 mmHg, p < 0.01, respectively). Pulmonary capillary wedge pressure was only reduced by GTN (14.0 ± 5.6 to 7.2 ± 3.9 mmHg, p < 0.001), and there was no significant change in the cardiac index. Sleep studies revealed no significant improvement in markers of CSR severity, including AHI, central apnea index, and CSR cycle length following GTN or iloprost treatment. Significant decreases in blood pressure, mean oxygen saturation, and S3 sleep were documented during GTN infusion.

CONCLUSIONS:

Acute improvement of pulmonary congestion by GTN had no immediate impact on CSR severity. Future investigations must therefore include longer treatment periods and treatment regimens that have positive, rather than negative, additional effects on peripheral and central chemoreceptors and sleep structure.

TRIAL REGISTRATION:

German Clinical Trial Registry-ID:DRKS00000467 ( www.germanctr.de ).

• Authors: Thomas Bitter, Henrik Fox, Heidi Schmalgemeier, Birgit Wellmann, Andrea Zwenke, Jens Spiesshöfer, Zisis Dimitriadis, Dieter Horstkotte, Olaf Oldenburg
• Journal: Sleep & breathing = Schlaf & Atmung (Sleep Breath) Vol. 20 Issue 2 Pg. 795-804 (May 2016) ISSN: 1522-1709 [Electronic] Germany
• PMID: 26782102 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Nitroglycerin
• Iloprost

Topics

• Administration, Inhalation
• Aged
• Cardiac Catheterization
• Cardiac Output (drug effects)
• Cheyne-Stokes Respiration (drug therapy)
• Cross-Over Studies
• Double-Blind Method
• Female
• Heart Failure (drug therapy)
• Hemodynamics (drug effects)
• Humans
• Iloprost (therapeutic use)
• Infusions, Intravenous
• Lung (blood supply)
• Male
• Middle Aged
• Nitroglycerin (therapeutic use)
• Polysomnography (drug effects)
• Pulmonary Wedge Pressure (drug effects)