Maggot debridement therapy promotes diabetic foot wound healing by up-regulating endothelial cell activity.

Abstract

To determine the role of maggot debridement therapy (MDT) on diabetic foot wound healing, we compared growth related factors in wounds before and after treatment. Furthermore, we utilized human umbilical vein endothelial cells (HUVECs) to explore responses to maggot excretions/secretions on markers of angiogenesis and proliferation. The results showed that there was neo-granulation and angiogenesis in diabetic foot wounds after MDT. Moreover, significant elevation in CD34 and CD68 levels was also observed in treated wounds. In vitro, ES increased HUVEC proliferation, improved tube formation, and increased expression of vascular endothelial growth factor receptor 2 in a dose dependent manner. These results demonstrate that MDT and maggot ES can promote diabetic foot wound healing by up-regulating endothelial cell activity.

• Authors: Xinjuan Sun, Jin'an Chen, Jie Zhang, Wei Wang, Jinshan Sun, Aiping Wang
• Journal: Journal of diabetes and its complications (J Diabetes Complications) Vol. 30 Issue 2 Pg. 318-22 (Mar 2016) ISSN: 1873-460X [Electronic] United States
• PMID: 26782021 (Publication Type: Journal Article, Randomized Controlled Trial)
• Copyright: Copyright © 2016. Published by Elsevier Inc.

Chemical References

• Culture Media, Conditioned

Topics

• Animals
• Cell Proliferation (drug effects)
• Cells, Cultured
• Culture Media, Conditioned (metabolism, pharmacology)
• Debridement (methods)
• Diabetic Foot (pathology, physiopathology, therapy)
• Endothelial Cells (drug effects, physiology)
• Human Umbilical Vein Endothelial Cells (drug effects, physiology)
• Humans
• Larva (metabolism)
• Neovascularization, Physiologic (drug effects, physiology)
• Up-Regulation
• Wound Healing (drug effects, physiology)