Changes in four plasma adipokines before and after sleep in OSAS patients.

Abstract

OBJECTIVES:

This study aimed to investigate whether plasma levels of four adipokines (chemerin, macrophage migratory inhibitory factor [MIF], visceral adipose tissue-derived serine protease inhibitor [vaspin] and chemokine CXCL5) are associated with the presence of obstructive sleep apnea syndrome (OSAS) in patients.

METHODS:

A total of 58 male patients with OSAS and 16 healthy male subjects were enrolled in this study.

RESULTS:

Four plasma adipokines (chemerin, MIF, vaspin and chemokine CXCL5) were significantly higher (P < 0.05) in severe OSAS patients than in the control group after polysomnography. Plasma levels of these four adipokines were higher (P < 0.05) after sleep than before sleep. These levels were also associated with anthropometric measurements for BMI, neck circumference, body fat percentage, sleep parameters including the apnea/hypopnea index (AHI) and minimum SaO2 %. Multiple regression analyses showed that BMI, AHI and mean SaO2 % were major factors affecting the four plasma adipokine levels in OSAS patients.

CONCLUSIONS:

Plasma chemerin, MIF, vaspin and chemokine CXCL5 levels were severely elevated with OSAS, and were also connected with obesity.

• Authors: Ting Xu, Yong Lin, Siqing Sun, Qiang Zhang
• Journal: The clinical respiratory journal (Clin Respir J) Vol. 11 Issue 6 Pg. 968-974 (Nov 2017) ISSN: 1752-699X [Electronic] England
• PMID: 26780194 (Publication Type: Journal Article)
• Copyright: © 2016 John Wiley & Sons Ltd.

Chemical References

• Adipokines
• Chemokine CXCL5
• Chemokines
• Intercellular Signaling Peptides and Proteins
• Leukocyte L1 Antigen Complex
• RARRES2 protein, human
• SERPINA12 protein, human
• Serpins

Topics

• Adipokines (blood)
• Adult
• Aged
• Anthropometry (methods)
• Body Fat Distribution
• Body Mass Index
• Chemokine CXCL5 (blood)
• Chemokines (blood)
• Humans
• Hypoxia (complications)
• Intercellular Signaling Peptides and Proteins (blood)
• Leukocyte L1 Antigen Complex (blood)
• Male
• Middle Aged
• Obesity (complications)
• Polysomnography (methods)
• Serpins (blood)
• Sleep (physiology)
• Sleep Apnea, Obstructive (blood, physiopathology)