Short-term results of platelet-rich plasma as adjuvant to 23-G vitrectomy in the treatment of high myopic macular holes.

Abstract

PURPOSE:

To investigate the short-term safety and efficacy of autologous platelet-rich plasma (a-PRP) as adjuvant to pars plana vitrectomy (PPV) with internal limiting membrane (ILM) peeling in the treatment of highly myopic macular holes (MH).

METHODS:

This was a prospective, nonrandomized interventional case series. Patients with MH associated with high myopia, with or without previous PPV, were included. All patients underwent 23-G PPV with the use of a-PRP. Anatomical and functional results of surgery were recorded.

RESULTS:

We included 7 eyes of 6 patients with highly myopic MH. Primary anatomical success was achieved in 7 out of 7 eyes. Mean best-corrected visual acuity improved by more than 1 line from baseline (0.66 ± 0.36 LogMAR) to final visit (0.52 ± 0.25 logMAR), but with no statistically significant difference (p = 0.246, Wilcoxon test). No surgical-related complications were noticed.

CONCLUSIONS:

The use of a-PRP as adjuvant to PPV with ILM peeling is effective in the treatment of highly myopic MH. This approach may represent a valid alternative to the inverted ILM flap technique, with comparable visual and anatomical results and the advantage of a simpler procedure. Further studies are necessary to confirm its usefulness in the management of high myopic MH.

• Authors: Marta S Figueroa, Andrea Govetto, Pablo de Arriba-Palomero
• Journal: European journal of ophthalmology (Eur J Ophthalmol) Vol. 26 Issue 5 Pg. 491-6 (Aug 04 2016) ISSN: 1724-6016 [Electronic] United States
• PMID: 26742873 (Publication Type: Journal Article)

Chemical References

• Fluorocarbons
• Silicone Oils
• perflutren

Topics

• Aged
• Basement Membrane (surgery)
• Endotamponade
• Female
• Fluorocarbons (administration & dosage)
• Humans
• Intravitreal Injections
• Male
• Middle Aged
• Myopia, Degenerative (complications, diagnostic imaging, therapy)
• Platelet-Rich Plasma
• Prospective Studies
• Retinal Perforations (diagnostic imaging, etiology, therapy)
• Retrospective Studies
• Silicone Oils (administration & dosage)
• Tomography, Optical Coherence
• Treatment Outcome
• Visual Acuity
• Vitrectomy