Morbidity in preterm infants with fetal inflammatory response syndrome.

Abstract

BACKGROUND:

The aim of this study was to evaluate the relationship between umbilical cord blood interleukin (IL)-6 concentration and preterm morbidity and mortality in premature infants born with fetal inflammatory response syndrome (FIRS).

METHODS:

This prospective, observational study included 84 preterm infants with a gestational age of 24-36 weeks who had been admitted to the neonatal intensive care unit (NICU). FIRS was defined as umbilical cord blood IL-6 > 11 pg/mL. In premature infants with FIRS, morbidities (multiple organ failure [MOF], respiratory distress syndrome [RDS], patent ductus arteriosus, intraventricular hemorrhage, bronchopulmonary dysplasia, retinopathy of prematurity) and death were evaluated. Critical umbilical cord blood IL-6 concentrations for the development of RDS, death, and for MOF were determined in premature infants with FIRS.

RESULTS:

Fifty-two infants with IL-6 concentration > 11 pg/mL constituted the FIRS group. Thirty-two infants without FIRS served as a control group. RDS, MOF, and mortality were significantly higher in the FIRS group (P = 0.001, P = 0.001, and P = 0.005, respectively). Umbilical cord blood IL-6 concentration > 26.7 pg/mL in the FIRS group was found to be predictive of RDS, with 70% sensitivity and 85% specificity. Umbilical cord blood IL-6 concentration > 37.7 pg/mL was found to be predictive of death, with 78.6% sensitivity and 60% specificity. The predictive value of IL-6 for the development of MOF was 17.5 pg/mL, with 91% sensitivity and 66% specificity.

CONCLUSIONS:

Umbilical cord blood IL-6 concentration > 26.7, 37.7, and 17.5 pg/mL in premature infants with FIRS was found to be predictive for RDS, death, and MOF, respectively.

• Authors: Elif Ozalkaya, Güner Karatekin, Sevilay Topcuoğlu, Tuğba Gürsoy, Fahri Ovalı
• Journal: Pediatrics international : official journal of the Japan Pediatric Society (Pediatr Int) Vol. 58 Issue 9 Pg. 850-4 (Sep 2016) ISSN: 1442-200X [Electronic] Australia
• PMID: 26717268 (Publication Type: Journal Article, Observational Study)
• Copyright: © 2015 Japan Pediatric Society.

Chemical References

• Interleukin-6

Topics

• Female
• Fetal Blood
• Follow-Up Studies
• Humans
• Infant, Newborn
• Infant, Premature
• Infant, Premature, Diseases (blood, epidemiology)
• Intensive Care Units, Neonatal
• Interleukin-6 (blood)
• Male
• Morbidity (trends)
• Prospective Studies
• Respiratory Distress Syndrome, Newborn (blood, epidemiology)
• Turkey (epidemiology)