Abstract |
Effects of intravenous antagonists of excitatory amino acids on decerebrate rigidity in the rat were examined. Kynurenate, ketamine, (4S, 5R)-4-(2-methylpropyl)-3-[3-(perhydroazepin-1-yl)propyl]-5-phenyl- 1,3- oxazolidin-2-one hydrochloride (MLV-6976), (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d] cyclo-hepten-5,10-imine maleate (MK-801), 3-((/-)-2-carboxypiperazin-4-yl)-propyl-1- phosphonic acid ( CPP) and DL-2-amino-7-phosphonoheptanoic acid (APH) reduced the severity of decerebrate rigidity in a dose-dependent manner, although there was a large variability in the effective doses. The blood pressure, which was determined simultaneously, did not show a uniform change in the presence of these antagonists. The time course of the change of the blood pressure did not coincide with that of decerebrate rigidity. These results suggest a possibility that the glutamatergic system may function, at least in part, in the onset of the decerebrate rigidity.
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Authors | H Shinozaki, M Ishida, Y Goto |
Journal | Neuropharmacology
(Neuropharmacology)
Vol. 28
Issue 6
Pg. 593-8
(Jun 1989)
ISSN: 0028-3908 [Print] England |
PMID | 2666874
(Publication Type: Journal Article)
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Chemical References |
- Amino Acids
- Anticonvulsants
- Azepines
- Dibenzocycloheptenes
- Muscle Relaxants, Central
- Oxazoles
- Oxazolidinones
- Piperazines
- MLV 6976
- Ketamine
- Dizocilpine Maleate
- 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid
- Kynurenic Acid
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Topics |
- Amino Acids
(antagonists & inhibitors)
- Animals
- Anticonvulsants
(pharmacology)
- Azepines
(pharmacology)
- Blood Pressure
(drug effects)
- Decerebrate State
- Dibenzocycloheptenes
(pharmacology)
- Dizocilpine Maleate
- Ketamine
(pharmacology)
- Kynurenic Acid
(pharmacology)
- Male
- Muscle Relaxants, Central
(pharmacology)
- Muscle Rigidity
(physiopathology)
- Oxazoles
(pharmacology)
- Oxazolidinones
- Piperazines
(pharmacology)
- Rats
- Rats, Inbred Strains
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