[RS3PE syndrome associated with senile Epstein-Barr virus-positive diffuse large B cell lymphoma of a patient with colon cancer].

Abstract

A 75-year-old woman consulted her doctor in January 2014 because of pain in the dorsum of the hands, elbows, shoulders, and knees, bilaterally, and was diagnosed as having remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome. Although the joint pain improved with low-dose prednisolone administration, she was referred to our department in April of 2014 because she had become aware of swelling of the right cervical lymph node. Biopsy of the lymph node demonstrated that she had Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma (DLBCL) of the elderly, and colonoscopy revealed early colon cancer. Also, both the lymphoma and colon cancer stained positive for vascular endothelial growth factor (VEGF). Complete remission was achieved after two courses of R-CHOP, and RS3PE syndrome did not relapse. This case suggested the involvement of VEGF produced by EBV-positive DLBCL in the pathogenesis of RS3PE syndrome.

• Authors: Saori Shimoyama, Hiroyuki Kuroda, Masahiro Yoshida, Makoto Usami, Hiroki Sakamoto, Michiko Yamada, Shigeyuki Fujii, Masahiro Maeda, Miri Fujita, Tatsumi Nakano, Yusuke Kanari, Satoshi Iyama, Junji Kato
• Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology (Rinsho Ketsueki) Vol. 56 Issue 11 Pg. 2329-35 (Nov 2015) ISSN: 0485-1439 [Print] Japan
• PMID: 26666720 (Publication Type: Case Reports, Journal Article, Review)

Chemical References

• Antibodies, Monoclonal, Murine-Derived
• R-CHOP protocol
• Rituximab
• Vincristine
• Doxorubicin
• Cyclophosphamide
• Prednisone

Topics

• Aged
• Antibodies, Monoclonal, Murine-Derived (therapeutic use)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Biopsy
• Colonic Neoplasms
• Cyclophosphamide (therapeutic use)
• Doxorubicin (therapeutic use)
• Epstein-Barr Virus Infections
• Female
• Humans
• Lymphoma, Large B-Cell, Diffuse (drug therapy)
• Prednisone (therapeutic use)
• Remission Induction
• Rituximab
• Synovitis (complications)
• Vincristine (therapeutic use)