Abstract |
Norepinephrine is a neurotransmitter that signals by stimulating the α1, α2 and β adrenergic receptor (AR). We determined the role of these receptors in regulating the immediate early genes, Activity Regulated Cytoskeleton Associated Protein ( Arc) and Zif268 in the rat cerebral cortex. RX821002, an α2-AR antagonist, produced Arc and Zif268 elevations across cortical layers. Next we examined the effects of delivering RX821002 with an α1-AR antagonist, prazosin, and a β-AR antagonist, propranolol. RX821002 given with a prazosin and propranolol cocktail, or with each of these antagonists individually, decreased Arc and Zif268 to saline-treated control levels in most cortical layers. Arc and Zif268 levels were also similar to saline-treated control levels when rats were given a prazosin and propranolol cocktail alone, or when each of these antagonists were delivered individually. Taken together, these data reveal that α2-AR uniquely exert a tonic inibitory regulation of both Arc and Zif268 compared to α1 and β-AR. However, the ability of RX821002 to increase Arc and Zif268 is interdependent with α1 and β-AR signaling.
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Authors | Norah Essali, Jeff Sanders |
Journal | Neuroscience letters
(Neurosci Lett)
Vol. 612
Pg. 38-42
(Jan 26 2016)
ISSN: 1872-7972 [Electronic] Ireland |
PMID | 26655475
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2015 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Adrenergic Antagonists
- Cytoskeletal Proteins
- Early Growth Response Protein 1
- Egr1 protein, rat
- Nerve Tissue Proteins
- RNA, Messenger
- Receptors, Adrenergic
- Receptors, Adrenergic, alpha-1
- Receptors, Adrenergic, alpha-2
- Receptors, Adrenergic, beta
- activity regulated cytoskeletal-associated protein
- Propranolol
- 2-methoxyidazoxan
- Prazosin
- Idazoxan
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Topics |
- Adrenergic Antagonists
(pharmacology)
- Animals
- Cerebral Cortex
(metabolism)
- Cytoskeletal Proteins
(genetics, metabolism)
- Early Growth Response Protein 1
(genetics, metabolism)
- Idazoxan
(analogs & derivatives, pharmacology)
- Nerve Tissue Proteins
(genetics, metabolism)
- Prazosin
(pharmacology)
- Propranolol
(pharmacology)
- RNA, Messenger
(metabolism)
- Rats, Sprague-Dawley
- Receptors, Adrenergic
(metabolism)
- Receptors, Adrenergic, alpha-1
(metabolism)
- Receptors, Adrenergic, alpha-2
(metabolism)
- Receptors, Adrenergic, beta
(metabolism)
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