The Estrogen Receptor-β Expression in De Quervain's Disease.

Abstract

Stenosing tenosynovitis of the first dorsal compartment of the wrist (a.k.a. de Quervain's disease) is common but how estrogen is involved is still unknown. We previously reported that inflammation was involved in the pathogenesis of this ailment. In the present study, we extended our investigation of estrogen receptor (ER)-β expression to determine whether estrogen is involved in the pathogenesis of de Quervain's. Intraoperative retinaculum samples were collected from 16 patients with the ailment. Specimens were histologically graded by collagen structure and immunohistochemically evaluated by quantifying the expression of ER-β, interleukin (IL)-1β and IL-6 (inflammatory cytokines), cyclooxygenase (COX)-2 (an inflammatory enzyme), and vascular endothelial growth factor (VEGF), and Von Willebrand's factor (vWF). De Quervain's occurs primarily in women. The female:male ratio in our study was 7:1. We found that ER-β expression in the retinaculum was positively correlated with disease grade and patient age. Additionally, disease severity was associated with inflammatory factors--IL-1β and IL-6, COX-2, and VEGF and vWF in tenosynovial tissue. The greater the levels of ER-β expression, tissue inflammation, and angiogenesis are, the more severe de Quervain's disease is. ER-β might be a useful target for novel de Quervain's disease therapy.

• Authors: Po-Chuan Shen, Ping-Hui Wang, Po-Ting Wu, Kuo-Chen Wu, Jeng-Long Hsieh, I-Ming Jou
• Journal: International journal of molecular sciences (Int J Mol Sci) Vol. 16 Issue 11 Pg. 26452-62 (Nov 04 2015) ISSN: 1422-0067 [Electronic] Switzerland
• PMID: 26556342 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Angiogenesis Inducing Agents
• Estrogen Receptor beta
• Inflammation Mediators

Topics

• Adult
• Age Factors
• Aged
• Angiogenesis Inducing Agents (metabolism)
• Case-Control Studies
• De Quervain Disease (diagnosis, genetics, metabolism, therapy)
• Estrogen Receptor beta (genetics, metabolism)
• Female
• Gene Expression Regulation
• Humans
• Immunohistochemistry
• Inflammation (genetics, metabolism, pathology)
• Inflammation Mediators (metabolism)
• Male
• Middle Aged
• Neovascularization, Pathologic (genetics, metabolism)
• Risk Factors
• Severity of Illness Index