Abstract | PURPOSE: Cutaneous adverse reactions (cADRs) from carbamazepine (CBZ) have been associated with human leukocyte antigens (HLA). Our aims were to assess the clinical usefulness of HLA-A*31:01 as a predictor of CBZ-induced cADRs in the Norwegian population and to explore whether cADRs from aromatic antiepileptic drugs (AEDs) in general might be linked with a common HLA-A-marker. MATERIALS AND METHODS: 86 ethnic Norwegians with a history of non-bullous cADRs from aromatic AEDs were included. 114 subjects tolerant to at least one aromatic AED were used as drug-specific controls. Complete HLA-A genotyping was performed. 1026 blood donors were used as population controls. RESULTS: Comparing all cADR subjects with controls and blood donors, there were no statistical differences for any HLA-A allele, except for HLA-A*24 (p=0.022 vs. controls and p=0.014 vs. blood donors). When comparing tolerant controls with patients having had a cADR to one of the two most used drugs, CBZ (n=48) and lamotrigine (n=28), we found no significant associations for CBZ to HLA-A*31:01 or HLA-A*24:02, but for lamotrigine there was an association with HLA-A*24:02 (p=0.027). In patients developing cross-reactivity (n=14) to aromatic AEDs, the presence of HLA-A*31:01 or HLA-A*24:02 was not different compared to patients with a single cARD tolerant to at least one other drug. CONCLUSION: We question the clinical usefulness of HLA-A*31:01 as a marker for CBZ rash in the Norwegian population. A previously suggested protective effect of aromatic AED cross-reactivity from HLA-A*24:02 was not confirmed. The association between HLA-A*24:02 and lamotrigine-induced rash should be further investigated.
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Authors | Maryam Shirzadi, Ketil Thorstensen, Grethe Helde, Torolf Moen, Eylert Brodtkorb |
Journal | Epilepsy research
(Epilepsy Res)
Vol. 118
Pg. 5-9
(Dec 2015)
ISSN: 1872-6844 [Electronic] Netherlands |
PMID | 26555631
(Publication Type: Journal Article)
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Copyright | Copyright © 2015 Elsevier B.V. All rights reserved. |
Chemical References |
- Anticonvulsants
- HLA-A*03:01 antigen
- HLA-A*24:02 antigen
- HLA-A24 Antigen
- HLA-A3 Antigen
- Triazines
- Carbamazepine
- Lamotrigine
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Topics |
- Adult
- Anticonvulsants
(adverse effects)
- Carbamazepine
(adverse effects)
- Case-Control Studies
- Cross Reactions
- Epilepsy
(drug therapy)
- Female
- Genetic Predisposition to Disease
(genetics)
- HLA-A24 Antigen
(genetics)
- HLA-A3 Antigen
(genetics)
- Humans
- Lamotrigine
- Male
- Norway
- Triazines
(adverse effects)
- Vasculitis, Leukocytoclastic, Cutaneous
(chemically induced, genetics)
- White People
(genetics)
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