Abstract | BACKGROUND AND PURPOSE: MATERIALS AND METHODS: MR elastography was performed on 10 patients with normal pressure hydrocephalus and 21 age- and sex-matched volunteers with no known neurologic disorders. Image acquisition was conducted on a 3T MR imaging scanner. Shear waves with 60-Hz vibration frequency were transmitted into the brain by a pillowlike passive driver. A novel postprocessing technique resistant to noise and edge artifacts was implemented to determine regional brain stiffness. The Wilcoxon rank sum test and linear regression were used for statistical analysis. RESULTS: A significant increase in stiffness was observed in the cerebrum (P = .001), occipital lobe (P < .001), parietal lobe (P = .001), and the temporal lobe (P = .02) in the normal pressure hydrocephalus group compared with healthy controls. However, no significant difference was noted in other regions of the brain, including the frontal lobe (P = .07), deep gray and white matter (P = .43), or cerebellum (P = .20). CONCLUSIONS: This study demonstrates increased brain stiffness in patients with normal pressure hydrocephalus compared with age- and sex-matched healthy controls; these findings should motivate future studies investigating the use of MR elastography for this condition and the efficacy of shunt therapy.
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Authors | N Fattahi, A Arani, A Perry, F Meyer, A Manduca, K Glaser, M L Senjem, R L Ehman, J Huston |
Journal | AJNR. American journal of neuroradiology
(AJNR Am J Neuroradiol)
Vol. 37
Issue 3
Pg. 462-7
(Mar 2016)
ISSN: 1936-959X [Electronic] United States |
PMID | 26542235
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | © 2016 by American Journal of Neuroradiology. |
Topics |
- Adult
- Aged
- Brain
- Elasticity Imaging Techniques
- Female
- Humans
- Hydrocephalus, Normal Pressure
(diagnosis)
- Image Interpretation, Computer-Assisted
(methods)
- Magnetic Resonance Imaging
(methods)
- Male
- Middle Aged
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