Correction of aberrant imprinting by allele-specific epigenome editing.

Abstract

Imprinting disorders are caused by the loss of the normal allele-specific DNA methylation at imprinting centers. Epigenetic editing is a promising approach to alter DNA methylation at defined genomic target regions. The novel development of CRISPR-Cas9-based DNA binding domains may allow for an allele-specific editing of DNA methylation at imprinted loci, for the first time offering a rational approach for correction of the molecular defects in imprinting disorders.

• Authors: P Bashtrykov, G Kungulovski, A Jeltsch
• Journal: Clinical pharmacology and therapeutics (Clin Pharmacol Ther) Vol. 99 Issue 5 Pg. 482-4 (May 2016) ISSN: 1532-6535 [Electronic] United States
• PMID: 26537177 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2015 American Society for Clinical Pharmacology and Therapeutics.

Topics

• Alleles
• CRISPR-Cas Systems (genetics)
• Chromosome Disorders (genetics)
• DNA Methylation (genetics)
• Epigenesis, Genetic (genetics)
• Epigenomics
• Genomic Imprinting (genetics)
• Humans