Complex relationship between sex hormones, insulin resistance and leptin in men with and without prostatic disease.

Abstract

OBJECTIVES:

To assess sex hormones, leptin and insulin-resistance in men with prostate cancer (PCa) and benign prostatic hyperplasia (BPH) and to study associations between androgens and histologic score of prostate tissue in PCa.

SUBJECTS AND METHODS:

Two hundred ten men older than 45 years selected from 2906 participants of a population screening for PCa were studied: 70 with PCa, 70 with BPH and 70 controls (CG), matched by body mass index and age. Insulin, IGF-1, PSA, leptin, total, free (fT) and bioavailable testosterone (bT) and estradiol were measured. Each group was subdivided into two subgroups considering the presence of metabolic syndrome (MS); androgens and leptin levels were analyzed in the subgroups.

RESULTS:

Prostate cancer and BPH patients presented higher total, fT and bT levels than CG. IGF-1, insulin and HOMA index were higher in BPH than in the other two groups. PCa presented higher leptin [median (range) 6.5 (1.3-28.0) versus 4.8 (1.1-12.3) ng/ml; p < 0.01] and estradiol [median (range) 37.0 (20-90) versus 29.0 (20-118) pg/ml; p = 0.025] levels than CG. After dividing men considering the presence of MS, leptin was higher and total testosterone was lower in MS patients in all the groups.

CONCLUSIONS:

It was observed a coexistence of an altered hormone profile with increased sex hormones and leptin in PCa patients, in accordance with the new perspective of PCa pathogenesis.

• Authors: Halina Grosman, Bibiana Fabre, Miguel Lopez, Carlos Scorticati, Maximiliano Lopez Silva, Viviana Mesch, Osvaldo Mazza, Gabriela Berg
• Journal: The aging male : the official journal of the International Society for the Study of the Aging Male (Aging Male) Vol. 19 Issue 1 Pg. 40-5 ( 2016) ISSN: 1473-0790 [Electronic] England
• PMID: 26526283 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Insulin
• Leptin
• Testosterone
• Estradiol
• Insulin-Like Growth Factor I
• Prostate-Specific Antigen

Topics

• Aged
• Case-Control Studies
• Estradiol (blood, physiology)
• Humans
• Insulin (blood)
• Insulin Resistance (physiology)
• Insulin-Like Growth Factor I (analysis)
• Leptin (blood)
• Male
• Metabolic Syndrome (blood, physiopathology)
• Middle Aged
• Prostate (pathology)
• Prostate-Specific Antigen (blood)
• Prostatic Hyperplasia (blood, physiopathology)
• Prostatic Neoplasms (blood, pathology, physiopathology)
• Testosterone (blood, physiology)