Abstract | BACKGROUND: METHODS: This was a single-center, randomized, controlled trial in Tianjin, China; 180 individuals aged 65 years and older who had mild cognitive impairment were assigned randomly to one of two groups: (a) those treated with oral folic acid (400 µg/day) and (b) those treated via conventional treatment. Tests of cognitive performance and biomarkers were measured at baseline, 3 months, and 6 months. Analysis was by intention-to-treat. Changes in cognitive or clinical function were analyzed by repeated-measure analysis of variance or mixed-effects models. This trial has been registered with the trial number ChiCTR-TRC-13003227. RESULTS: Total of 159 participants (intervention group: 80; control group: 79) completed the trial. Repeated-measure analysis of variance showed significant improvements in serum folate (ηp (2) = 0.712, p = .009), homocysteine (ηp (2) = 0.119, p = .017), serum vitamin B12 (ηp (2) = 0.144, p = .022), and S-adenosylmethionine (ηp (2) = 0.117, p = .033) in the intervention group over the control group. Folic acid supplementation improved Full Scale IQ (p = .031; effect size d = 0.168), Digit Span (p = .009; d = 0.176), and Block Design (p = .036; effect size d = 0.146) scores at 6 months in comparison to the control. There were no significant findings for all other cognitive measures. CONCLUSION: There was a beneficial effect from relatively short-term folate supplementation on cognitive functioning in later life. Larger-scale, randomized, controlled trials of longer duration in selected age groups are needed.
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Authors | Fei Ma, Tianfeng Wu, Jiangang Zhao, Fengmei Han, Anna Marseglia, Huan Liu, Guowei Huang |
Journal | The journals of gerontology. Series A, Biological sciences and medical sciences
(J Gerontol A Biol Sci Med Sci)
Vol. 71
Issue 10
Pg. 1376-83
(10 2016)
ISSN: 1758-535X [Electronic] United States |
PMID | 26508298
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | © The Author 2015. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: [email protected]. |
Chemical References |
- Biomarkers
- Homocysteine
- Folic Acid
- Vitamin B 12
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Topics |
- Aged
- Biomarkers
(blood)
- China
- Cognitive Dysfunction
(drug therapy)
- Female
- Folic Acid
(administration & dosage)
- Homocysteine
(blood)
- Humans
- Male
- Treatment Outcome
- Vitamin B 12
(blood)
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