Abstract | OBJECTIVE:
Bone resorption of distal phalanges, or acroosteolysis (AO), can develop in patients with systemic sclerosis (SSc), causing pain and functional limitation. This study was undertaken to investigate whether AO may be associated with abnormal osteoclastogenesis in SSc patients and whether hypoxia may be involved in this process. METHODS: RESULTS: SSc patients with AO formed significantly more osteoclasts after 9 days than did patients without AO (mean ± SD 142.4 ± 67.0 versus 27.2 ± 17.6 MGCs/well; P < 0.001) or healthy controls (mean ± SD 18.7 ± 27.0 MGCs/well; P < 0.001). No significant difference in osteoclast formation was noted between the patients without AO and healthy controls. Plasma levels of VEGF were higher in SSc patients with AO compared to those without (mean ± SD 142.4 ± 69.6 pg/ml versus 88.1 ± 38.2 pg/ml; P < 0.005) or healthy controls (54.2 ± 24.6 pg/ml; P = 0.018). Priming with VEGF-A for 24 hours significantly increased osteoclast generation by 5.3 ± 1.9 fold (P = 0.0018). The radiographic extent of AO was associated with increased osteoclast formation (Spearman's ρ = 0.741, P = 0.01). CONCLUSION: Our findings indicate that increased osteoclast formation and higher VEGF levels may contribute to AO in SSc patients. Further studies are needed to elucidate whether targeting osteoclastogenesis may provide a specific therapeutic option for SSc-associated AO.
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Authors | Jin Kyun Park, Andrea Fava, John Carrino, Filippo Del Grande, Antony Rosen, Francesco Boin |
Journal | Arthritis & rheumatology (Hoboken, N.J.)
(Arthritis Rheumatol)
Vol. 68
Issue 1
Pg. 201-9
(Jan 2016)
ISSN: 2326-5205 [Electronic] United States |
PMID | 26361270
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | © 2016, American College of Rheumatology. |
Chemical References |
- Isoenzymes
- RANK Ligand
- VEGFA protein, human
- Vascular Endothelial Growth Factor A
- Macrophage Colony-Stimulating Factor
- Acid Phosphatase
- Tartrate-Resistant Acid Phosphatase
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Topics |
- Acid Phosphatase
(metabolism)
- Acro-Osteolysis
(blood, diagnostic imaging, etiology)
- Adult
- Aged
- Bone Resorption
(metabolism)
- Case-Control Studies
- Cell Differentiation
- Female
- Finger Phalanges
(diagnostic imaging)
- Humans
- Isoenzymes
(metabolism)
- Leukocytes, Mononuclear
(cytology, metabolism)
- Macrophage Colony-Stimulating Factor
- Male
- Middle Aged
- Osteoclasts
(cytology, metabolism)
- RANK Ligand
- Radiography
- Scleroderma, Systemic
(blood, complications, diagnostic imaging)
- Tartrate-Resistant Acid Phosphatase
- Vascular Endothelial Growth Factor A
(blood)
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