Serum IL-6 and IL-23 Levels and Their Correlation with Angiogenic Cytokines and Disease Activity in Ankylosing Spondylitis, Psoriatic Arthritis, and SAPHO Syndrome.

Abstract

OBJECTIVES:

To assess serum interleukin-6 (IL-6) and interleukin-23 (IL-23) and their correlation with angiogenic cytokines and disease activity in ankylosing spondylitis (AS), psoriatic arthritis (PsA), and SAPHO syndrome.

PATIENTS AND METHODS:

We studied 152 spondyloarthritis (SpA) patients: 69 PsA, 61 AS, 22 SAPHO, and 29 controls. We recorded age, sex, disease duration, and treatment. We assessed BASDAI, VAS, and PASI scores. Serum IL-6, IL-23, VEGF, EGF, FGFb, and FGFa levels were determined using ELISA. We estimated ESR and CRP.

RESULTS:

Serum IL-6 and IL-23 levels were higher in SpA than in control (P < 0.00001 and P = 0.0004, resp.). There was a positive correlation between serum IL-6 and CRP in AS (P = 0.000001), PsA (P = 0.000001), and SAPHO (P = 0.0003) patients. There was a positive correlation between serum IL-6 and ESR in AS (P = 0.000001), PsA (P = 0.002), and SAPHO (P = 0.02) patients. There was no correlation of serum IL-6 and IL-23 with VAS, BASDAI, and angiogenic cytokines in SpA.

CONCLUSIONS:

Serum IL-6 but not serum IL-23 correlated with ESR and CRP in SpA. No correlation was found of serum IL-6 and IL-23 with VAS, BASDAI, and angiogenic cytokines.

• Authors: Hanna Przepiera-Będzak, Katarzyna Fischer, Marek Brzosko
• Journal: Mediators of inflammation (Mediators Inflamm) Vol. 2015 Pg. 785705 ( 2015) ISSN: 1466-1861 [Electronic] United States
• PMID: 26339141 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cytokines
• IL6 protein, human
• Interleukin-23
• Interleukin-6
• Vascular Endothelial Growth Factor A
• Fibroblast Growth Factors
• Epidermal Growth Factor

Topics

• Acquired Hyperostosis Syndrome (blood)
• Adult
• Arthritis, Psoriatic (blood)
• Cytokines (blood)
• Epidermal Growth Factor (blood)
• Female
• Fibroblast Growth Factors (blood)
• Humans
• Interleukin-23 (blood)
• Interleukin-6 (blood)
• Male
• Middle Aged
• Spondylitis, Ankylosing (blood)
• Vascular Endothelial Growth Factor A (blood)