Abstract | BACKGROUND:
Epidermal growth factor receptor inhibitors are recent antineoplastic treatments used for the treatment of some non-cutaneous tumours, which aberrantly express EGFR. Because of their specificity, these drugs have low systemic toxicity, but frequent undesired cutaneous effects, the most common of which is an acneiform eruption, occurring after 1-3 weeks of treatment. Management of this rash is not well standardized. OBJECTIVE: METHODS: Patients applied the clindamycin phosphate- benzoyl peroxide gel once daily, at evening, for 8 weeks. The Skin-Score was used to evaluate reduction of erythema, papules, pustules and pruritus, the Dermatology Life Quality Index questionnaire to evaluate the improvements of health-related quality of life. RESULTS: Significant clinical improvements occurred after 2 weeks of treatment and were even more evident after 8 weeks (mean Skin-Score 20.54 ± 7.83, p = 1.37 × 10(-6) vs. second week visit, p = 1.26 × 10(-7) vs. before treatment). Accordingly, DLQI values decreased from 13.64 ± 2.01 before treatment to 6.45 ± 1.37 after 8 weeks (p = 1.12 × 10(-5)). CONCLUSION:
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Authors | Mario Vaccaro, Fabrizio Guarneri, Francesco Borgia, Andrea Pollicino, Giuseppe Altavilla, Serafinella P Cannavò |
Journal | The Journal of dermatological treatment
(J Dermatolog Treat)
Vol. 27
Issue 2
Pg. 148-52
( 2016)
ISSN: 1471-1753 [Electronic] England |
PMID | 26313697
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Anti-Bacterial Agents
- Antineoplastic Agents
- Gels
- Clindamycin
- clindamycin phosphate
- Cetuximab
- Benzoyl Peroxide
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Topics |
- Acneiform Eruptions
(chemically induced, drug therapy)
- Administration, Cutaneous
- Aged
- Anti-Bacterial Agents
(administration & dosage)
- Antineoplastic Agents
(adverse effects, therapeutic use)
- Benzoyl Peroxide
(administration & dosage)
- Cetuximab
(administration & dosage, adverse effects)
- Clindamycin
(administration & dosage, analogs & derivatives)
- Colorectal Neoplasms
(drug therapy)
- Erythema
(chemically induced, drug therapy)
- Follow-Up Studies
- Gels
- Humans
- Male
- Middle Aged
- Pruritus
(drug therapy)
- Quality of Life
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