The Role of PET [18F]FDOPA in Evaluating Low-grade Glioma.

Abstract

AIM:

The aim of the present study was to evaluate the prognostic value of 3,4-dihydroxy-6-[(18)F]-fluoro-L-phenylalanine ([(18)F]-FDOPA) positron-emission tomography (PET) in predicting the risk of radiological progression of disease in patients affected by low-grade glioma.

PATIENTS AND METHODS:

Patients affected by grade II glioma were consecutively enrolled in a prospective observational study at the Department of Neurology of Regina Elena National Cancer Institute in Rome, Italy. At enrolment, all patients underwent PET [(18)F]-FDOPA and Magnetic Resonance Imaging (MRI), and clinical and radiological assessments with MRI every six months to evaluate the progression of disease.

RESULTS:

A total of 50 patients affected by grade II glioma (30 males and 20 females) were included in the study. The multivariate analysis showed that standardized uptake value greater than 1.75 and disease duration were independent predictors of disease progression.

CONCLUSION:

These findings suggest that the PET [(18)F]-FDOPA may play an important prognostic role in evaluation of low-grade glioma.

• Authors: Veronica Villani, Carmine M Carapella, Agostino Chiaravalloti, Irene Terrenato, Francesca Piludu, Antonello Vidiri, Orazio Schillaci, Roberto Floris, Simona Marzi, Alessandra Fabi, Andrea Pace
• Journal: Anticancer research (Anticancer Res) Vol. 35 Issue 9 Pg. 5117-22 (Sep 2015) ISSN: 1791-7530 [Electronic] Greece
• PMID: 26254416 (Publication Type: Journal Article, Observational Study)
• Copyright: Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

Chemical References

• Fluorodeoxyglucose F18
• Dihydroxyphenylalanine

Topics

• Adult
• Aged
• Brain Neoplasms (diagnostic imaging)
• Demography
• Dihydroxyphenylalanine
• Disease Progression
• Female
• Fluorodeoxyglucose F18
• Follow-Up Studies
• Glioma (diagnostic imaging)
• Humans
• Magnetic Resonance Imaging
• Male
• Middle Aged
• Multivariate Analysis
• Positron-Emission Tomography
• Prognosis
• Proportional Hazards Models
• ROC Curve
• Young Adult