Green Synthesis of Oxovanadium(IV)/chitosan Nanocomposites and Its Ameliorative Effect on Hyperglycemia, Insulin Resistance, and Oxidative Stress.

Abstract

In this paper, the preparation, characterization, and ameliorative effect on high-fat high-sucrose diet-induced hyperglycemia, insulin resistance, oxidative stress in mice of novel oxovanadium(IV)/chitosan (OV/CS) nanocomposites were investigated. The nanobiocomposite was produced by chemical reduction by chitosan and L-ascorbic acid using microwave heating, under environment-friendly conditions, using aqueous solutions, and notably, by using both mediators as reducing and stabilizing agents. In addition, OV/CS nanocomposites were characterized by transmission electron microscopy, energy dispersive spectroscopy, particle size, and zeta potential measurements. In vivo experiments were designed to examine whether the OV/CS nanocomposites would provide additional benefits on oxidative stress, hyperglycemia, and insulin resistance in mice with type 2 diabetes. The results rendered insulin resistant by treating with OV/CS nanocomposites alleviate insulin resistance and improve oxidative stress. Such nanocomposite seem to be a valuable therapy to achieve and/or maintain glycemic control and therapeutic agents in the treatment arsenal for insulin resistance and type 2 diabetes.

• Authors: Yanjun Liu, Xu Jie, Yongli Guo, Xin Zhang, Jingfeng Wang, Changhu Xue
• Journal: Biological trace element research (Biol Trace Elem Res) Vol. 169 Issue 2 Pg. 310-9 (Feb 2016) ISSN: 1559-0720 [Electronic] United States
• PMID: 26144273 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• oxovanadium IV
• Vanadates
• Chitosan

Topics

• Animals
• Chitosan (chemistry, therapeutic use)
• Diabetes Mellitus, Experimental (drug therapy, metabolism)
• Diabetes Mellitus, Type 2 (drug therapy, metabolism)
• Drug Stability
• Glucose Tolerance Test
• Green Chemistry Technology
• Hyperglycemia (drug therapy, metabolism)
• Insulin Resistance
• Liver (drug effects, metabolism)
• Male
• Mice, Inbred C57BL
• Nanocomposites (chemistry, ultrastructure)
• Oxidative Stress (drug effects)
• Vanadates (chemistry, therapeutic use)