High mobility group box 1
protein (
HMGB1) was significantly increased in
coronary artery disease (CAD) with type 2 diabetic mellitus (T2DM) patients. This study was to investigate the relationship between average
blood glucose level and
HMGB1 level in CAD with T2DM patients. 164 CAD patients were divided into two groups: CAD with T2DM patients group and CAD without T2DM patients group. Glycated
albumin (GA) and
glycosylated hemoglobin A1c (HbA1c) and
HMGB1 concentrations were measured in CAD with T2DM patients. The fasting
glucose levels, GA and HbA1c levels were sinificantly increased in CAD with T2DM patients compared to those in CAD without T2DM patients (all P<0.05). The
hs-CRP levels in CAD with T2DM patients were significantly higher than those in CAD without T2DM patients (P<0.05). The
HMGB1 levels in CAD with T2DM patients were also significantly higher than those in CAD without T2DM patients (P<0.05). Both serum GA levels and HbA1c levels were positively correlated with
HMGB1 levels (n=84, r=0.512 and r=0.402, both P<0.05). The present study showed that both serum GA levels and HbA1c levels were positively related with
HMGB1 levels in CAD with T2DM patients. Increased
blood glucose levels may contribute to the increased
HMGB1 levels. GA level is superior to HbA1c level for correlating with
HMGB1 level.