The usefulness of a new triple combination treatment utilizing methotrexate, salazosulfapyridine, and bucillamine in rheumatoid arthritis.

Abstract

OBJECTIVES:

Combination treatment with methotrexate, salazosulfapyridine and bucillamine as an alternative to treatment with TNF-inhibiting biologics in rheumatoid arthritis was investigated.

METHODS:

Twenty-six facilities allied with the Japan Association of Rheumatologists in Private Practice participated in this study. One hundred and twelve patients enrolled in this study, all of whom were within 3 years of diagnosis with rheumatoid arthritis for whom treatment with one DMARD or a combination of two DMARDs had failed (DAS28 > 3.2). Patients chose their own treatment. The triple DMARDs combination group was comprised of 72 patients; the TNF-inhibiting biologics treatment group was comprised of 40 patients.

RESULTS:

DAS28 scores for the triple DMARDs combination group and the TNF-inhibiting biologics treatment groups were 4.84 ± 0.96 and 5.23 ± 1.26, and there was no significant difference between the two groups. From the 6th month, average disease activities of both groups were reduced, and there was no difference between the two groups at 12 months (DAS28, 3.39 ± 1.43 and 3.05 ± 1.43, p = 0.39). Furthermore, there was no significant difference in the degree of bone destruction between the two groups at 12 months.

CONCLUSIONS:

The triple DMARD combination therapy provided a new treatment option for those patients for whom treatment with biologics is difficult.

• Authors: Hiroaki Matsuno, Masato Okada, Yoshitada Sakai, Chiyuki Abe, Kou Katayama, Akira Sagawa, Kuniomi Yamasaki, Masakazu Kondo, Keiko Funahashi, Tsukasa Matsubara
• Journal: Modern rheumatology (Mod Rheumatol) Vol. 26 Issue 1 Pg. 51-6 ( 2016) ISSN: 1439-7609 [Electronic] England
• PMID: 26052803 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antirheumatic Agents
• Biological Products
• Sulfasalazine
• Cysteine
• bucillamine
• Methotrexate

Topics

• Adult
• Aged
• Antirheumatic Agents (therapeutic use)
• Arthritis, Rheumatoid (drug therapy)
• Biological Products (therapeutic use)
• Cysteine (analogs & derivatives, therapeutic use)
• Drug Therapy, Combination
• Female
• Humans
• Japan
• Male
• Methotrexate (therapeutic use)
• Middle Aged
• Sulfasalazine (therapeutic use)
• Treatment Outcome