Cost-effectiveness of stimulation of the sphenopalatine ganglion (SPG) for the treatment of chronic cluster headache: a model-based analysis based on the Pathway CH-1 study.

Abstract

BACKGROUND:

In the recent Pathway CH-1 study, on-demand stimulation of the sphenopalatine ganglion (SPG) by means of an implantable neurostimulation system was proven to be a safe and effective therapy for the treatment of chronic cluster headache. Our objective was to assess the cost-effectiveness of SPG stimulation in the German healthcare system when compared to medical management.

METHODS:

Clinical data from the Pathway CH-1 study were used as input for a model-based projection of the cost-effectiveness of SPG stimulation through 5 years. Medical management as the comparator treatment was modeled on the basis of clinical events observed during the baseline period of CH-1. The costs of treatment were derived from a previously published cluster headache costing study and 2014 medication, neurostimulator, and procedure costs. We computed the 5-year incremental cost-effectiveness ratio (ICER) in euros per quality-adjusted life year (QALY), with costs and effects discounted at 3 % per year.

RESULTS:

SPG stimulation was projected to add 0.325 QALYs over the study period, while adding €889 in cost, resulting in a 5-year ICER of €2,736 per QALY gained. Longer follow-up periods, higher baseline attack frequency, and higher utilization of attack-aborting medications led to overall cost savings. SPG stimulation was found either cost-effective or cost-saving across all scenarios investigated in sensitivity analyses.

CONCLUSIONS:

Our model-based analysis suggests that SPG stimulation for the treatment of chronic cluster headache, under the assumption of sustained therapy effectiveness, leads to meaningful gains in health-related quality of life and is a cost-effective treatment strategy in the German healthcare system.

• Authors: Jan B Pietzsch, Abigail Garner, Charly Gaul, Arne May
• Journal: The journal of headache and pain (J Headache Pain) Vol. 16 Pg. 530 ( 2015) ISSN: 1129-2377 [Electronic] England
• PMID: 26002638 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Adult
• Cluster Headache (therapy)
• Cost-Benefit Analysis
• Electric Stimulation Therapy (methods)
• Electrodes, Implanted
• Female
• Ganglia, Parasympathetic
• Health Care Costs
• Humans
• Male
• Middle Aged
• Pterygopalatine Fossa (innervation)
• Quality-Adjusted Life Years
• Treatment Outcome
• Young Adult